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SRP3126

Sigma-Aldrich

NP-1 Peptide

≥98% (HPLC), human recombinant, expressed in E. coli, suitable for cell culture

Sinónimos:

Cryptdin, HNP-1, Neutrophil Peptide-1, alpha Defensin-1

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

Nombre del producto

NP-1 human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

origen biológico

human

recombinante

expressed in E. coli

Ensayo

≥98% (HPLC)
≥98% (SDS-PAGE)

Formulario

lyophilized

mol peso

3.4 kDa

envase

pkg of 20 μg

técnicas

cell culture | mammalian: suitable

impurezas

<0.1 EU/μg endotoxin, tested

color

white to off-white

Nº de acceso UniProt

espectro de actividad antibiótica

fungi
mycobacteria
viruses

Modo de acción

cell membrane | interferes

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... NRP1(8829)

Descripción general

Chemical structure: peptide
Defensins (α and β) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins which include neutrophil peptides-1, -2 and -3, (NP-1, NP-2 and NP-3) are distinguished from the β-defensins by the pairing of their three disulfide bonds. Neutrophil-1 (NP-1) is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. The protein contains a six-cysteine motif that forms three intra-molecular disulfide bonds. It is a transmembrane glycoprotein. Recombinant human NP-1 is a 3.4kDa protein containing 30 amino acid residues.

Acciones bioquímicas o fisiológicas

Neutrophil peptide-1 (NP-1) exhibits antimicrobial activity. It also has a chemotactic function in dendritic cells. It has a role in the growth and metastasis of cancer cells. The protein acts as multifunctional co-receptor and interacts with various signaling cascades. NP-1 associates with epithelial growth factor (EGF) and its receptor (EGFR). It also interacts with hepatocyte growth factor (HGF) and its receptor c-Met.

Secuencia

ACYCRIPACI AGERRYGYCI YQGRLWAFCC

Forma física

Lyophilized with no additives.

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors.
Li L
Journal of Experimental & Clinical Cancer Research, 35, 16-16 (2016)
Haiyan Jia et al.
Chembiochem : a European journal of chemical biology, 15(8), 1161-1170 (2014-04-29)
The interaction between VEGF-A and its neuropilin (NRP) receptors mediates a number of important biological effects. NRP1 and the related molecule NRP2 are widely expressed on multiple tumour types and throughout the tumour vasculature, and are emerging as critical molecules
Pavel Melicherčík et al.
Diagnostics (Basel, Switzerland), 10(1) (2020-01-16)
The α-defensins (AD) present in synovial fluid have been regarded as constituting the most accurate periprosthetic joint infection (PJI) biomarker. The methods most commonly used for estimating AD as a biomarker are the qualitative Synovasure® PJI tests, based on the
Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines.
Varkey J and Nagaraj R
Antimicrobial Agents and Chemotherapy, 49(11), 4561-4566 (2005)
Y Q Tang et al.
Science (New York, N.Y.), 286(5439), 498-502 (1999-10-16)
Analysis of rhesus macaque leukocytes disclosed the presence of an 18-residue macrocyclic, tridisulfide antibiotic peptide in granules of neutrophils and monocytes. The peptide, termed rhesus theta defensin-1 (RTD-1), is microbicidal for bacteria and fungi at low micromolar concentrations. Antibacterial activity

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