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SML0152

Sigma-Aldrich

AK-7

≥98% (HPLC)

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About This Item

Fórmula empírica (notación de Hill):
C19H21BrN2O3S
Número de CAS:
420831-40-9
Peso molecular:
437.35
MDL number:
MFCD03140195
UNSPSC Code:
12352200
PubChem Substance ID:
329825200
NACRES:
NA.25

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)c1

InChI

1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)

InChI key

IYAYHZZWYNXHEQ-UHFFFAOYSA-N

General description

AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.

Application

AK-7 has been used in cell culture and cell treatment.

Biochem/physiol Actions

In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.
Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
Selective SIRT2 Inhibitor

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Nagako Sougawa et al.
Transplantation, 103(5), e119-e127 (2019-02-08)
The extracellular matrix, in particular basement membrane components such as laminins (LMs), is essential for stem cell differentiation and self-renewal. LM511 and LM221 are the main extracellular matrix components of the epicardium, where stem cells were abundant. Here, we examined
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models
Chopra V, et al.
Cell Reports, 2(6), 1492-1497 (2012)
Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7
Wang X,et al.
Drug design, development and therapy (2015)
Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders
Motyl J, et al.
Molecular Neurobiology, 55(1), 727-740 (2018)
Matthew A Kunicki et al.
Journal of immunology (Baltimore, Md. : 1950), 200(1), 336-346 (2017-11-29)
Human CD3
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