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Merck

S1820

Sigma-Aldrich

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt

≥98% (HPLC), lyophilized powder

Sinónimos:

PAR-1 (Protease-Activated Receptor) Selective Activating Peptide, PAR1-AP, SFLLRN-NH2

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About This Item

Fórmula lineal:
C34H57N11O8 · x CF3COOH
Número de CAS:
Peso molecular:
747.89 (free base basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32

assay

≥98% (HPLC)

form

lyophilized powder

color

white

UniProt accession no.

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O

InChI

1S/C34H57N11O8.C2HF3O2/c1-18(2)13-24(31(51)41-22(11-8-12-40-34(38)39)30(50)42-23(28(37)48)16-27(36)47)44-32(52)25(14-19(3)4)45-33(53)26(43-29(49)21(35)17-46)15-20-9-6-5-7-10-20;3-2(4,5)1(6)7/h5-7,9-10,18-19,21-26,46H,8,11-17,35H2,1-4H3,(H2,36,47)(H2,37,48)(H,41,51)(H,42,50)(H,43,49)(H,44,52)(H,45,53)(H4,38,39,40);(H,6,7)/t21-,22-,23-,24-,25-,26-;/m0./s1

InChI key

YICKZNIVMKPQPD-POCCEKOUSA-N

Gene Information

human ... IGF1R(3480)

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn-NH2

Application

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt has been used as a protease-activated receptor 1 (PAR-1) selective activating peptide.

Biochem/physiol Actions

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt (SFLLRN) acts as a protease-activated receptor 1 (PAR-1) specific agonist peptide.
Thrombin receptor activating peptide (TRAP).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

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Visite la Librería de documentos

J. S. Davies
Amino Acids, Peptides and Proteins, 29 (1998)
Thrombin induces Ca2+-dependent glutamate release from RPE cells mediated by PLC/PKC and reverse Na+/Ca2+ exchange
Lopez E, et al.
Molecular Vision (2019)
Nicola Maggio et al.
Hippocampus, 24(8), 1030-1038 (2014-04-23)
Thrombin and other clotting factors regulate long-term potentiation (LTP) in the hippocampus through the activation of the protease activated receptor 1 (PAR1) and consequent potentiation of N-methyl-d-aspartate receptor (NMDAR) functions. We have recently shown that the activation of PAR1 either
M Rijkers et al.
Vox sanguinis, 111(3), 247-256 (2016-10-22)
In mice, loss of sialic acid resulting in shedding of glycoprotein (GP) Ibα and GPV has been linked to platelet survival. The aim of this study was to determine whether loss of sialic acid and the GPIb-IX-V complex contributes to
Visualizing dynamics of cell signaling in vivo with a phase separation-based kinase reporter
Zhang Q, et al.
Molecular Cell, 69(2), 334-346 (2018)

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