R8526
RO-52 (SSA) human
recombinant, expressed in E. coli, liquid
Sinónimos:
Anti-RO-52 antibody
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About This Item
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in E. coli
Formulario
liquid
mol peso
52 kDa by SDS-PAGE
técnicas
ELISA: suitable
Nº de acceso UniProt
temp. de almacenamiento
−70°C
Información sobre el gen
human ... TRIM21(6737)
Descripción general
Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
Aplicación
RO-52 (SSA) human has been used:
- as a component of the autoantigen array
- to immobilise protein on the self-assembly monolayer
- in enzyme-linked immunosorbent assays (ELISAs)
Acciones bioquímicas o fisiológicas
RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
Forma física
solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
The Sjogren?s syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death
Espinosa A, et al.
Journal of Immunology, 176(10), 6277-6285 (2006)
Mapping molecular binding by means of conformational dynamics measurements
do Nascimento NM, et al.
Royal Society of Chemistry Advances, 8(2), 867-876 (2018)
New structural insights into the role of TROVE2 complexes in the on-set and pathogenesis of systemic lupus erythematosus determined by a combination of QCM-D and DPI
Juste-Dolz A, et al.
Analytical and Bioanalytical Chemistry, 1-12 (2018)
Accumulation of Antigen-Driven Lymphoproliferations in Complement Receptor 2/CD 21-/low B Cells From Patients With Sjogren's Syndrome
Glauzy S, et al.
Arthritis and Rheumatism, 70(2), 298-307 (2018)
TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis
Pan JA, et al.
Molecular Cell, 61(5), 720-733 (2016)
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