C0984

Creatine Kinase MB Fraction from human heart

≥70% (SDS-PAGE), liquid

• Sinónimos: CK MB Fraction
• Número MDL: MFCD00151686
• Código UNSPSC: 12352204
• NACRES: NA.54

Propiedades

• origen biológico: human heart
• Nivel de calidad: 200
• Ensayo: ≥70% (SDS-PAGE)
• Formulario: liquid
• concentración: ≥0.5 mg/mL
• técnicas: IR spectroscopy: suitable
• idoneidad: suitable for tissue
• Nº de acceso UniProt: P06732; P12277
• aplicaciones: pharmaceutical
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... CKB(1152) , CKM(1158)

Descripción

Descripción general

Research area: Cell Signaling
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.[1]

Aplicación

Creatine Kinase MB Fraction from human heart has been used:

• as a diagnostic marker for acute myocardial infarction.[2]
• to identify overlapping absorbance peaks between blood and the cardiac biomarkers.[3]
• to study the phosphorylation pathway of dioxolane guanosine (DXG) in vivo, a potential treatment of HIV-1 infection.[4]

Acciones bioquímicas o fisiológicas

Creatine Kinase (CK) catalyzes the formation of creatinine from creatine phosphate.[1] The enzyme is associated with coronary performance. Elevated serum levels of CK-MB are prime indicators of myocardial cellular injury.[1] It is regarded as a “gold standard” for myocardial infarction diagnosis.[1] The levels of cardiac troponin I (cTnI) or cardiac troponin T also correlate to higher CK-MB) levels.[5] CK-MB levels may also be elevated in chronic renal failure.[6]

Componentes

Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable