The storage stability of this product at -80°C has not been tested, and stability depends on factors such as solvent composition, freeze-thaw cycles, and storage conditions. Typical stock solutions can be prepared at concentrations of 50–500 mg solid (powder) in 1 ml water. Solutions should be stored in working aliquots at -20°C. This product can be stored in working aliquots in tightly sealed containers at -20°C for 6 months. Avoid repeated freeze-thaw cycles. More information can be found in the document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/859/e8014inf.pdf
P7556
Progesterone-Water Soluble
powder, BioReagent, suitable for cell culture
Sinónimos:
Progesterone: HBC complex, Progesterone: methyl-β-cyclodextrin complex
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About This Item
origen biológico:
synthetic (organic)
Formulario:
powder
Ensayo:
≥65% (HPLC)
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
origen biológico
synthetic (organic)
Nivel de calidad
Línea del producto
BioReagent
Ensayo
≥65% (HPLC)
Formulario
powder
concentración
≥65% (HPLC)
técnicas
cell culture | mammalian: suitable
solubilidad
H2O: 25 mg/mL, clear to slightly hazy
Condiciones de envío
ambient
temp. de almacenamiento
room temp
cadena SMILES
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
InChI
1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
Clave InChI
RJKFOVLPORLFTN-LEKSSAKUSA-N
Información sobre el gen
human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)
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Descripción general
Progesterone is a steroid hormone secreted by the ovaries.[1]
Aplicación
Progesterone-Water Soluble has been used:
- for in vitro maturation of oocyte complexes[2]
- as a σ1R antagonist to study its effect on sigma 1 receptor[3]
- to study its effect on the differentiation of human multipotent mesenchymal stromal cells (hMSCs) in vitro[4]
This product is not recommended for use in binding assays.
Acciones bioquímicas o fisiológicas
Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy.[5] It is known to prevent preterm delivery, when administered intramuscularly.[6] Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.[7]
Envase
Package size based on progesterone content
Otras notas
Contains approx. 70 mg progesterone per gram; balance methyl-β-cyclodextrin.
Producto relacionado
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Carc. 2 - Lact. - Repr. 1A
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
Lot/Batch Number
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Neurosteroid Hormones Modulate the Differentiation of Adult Human Multipotent Mesenchymal Stromal Cells
Tiftikcioglu BI, et al.
Journal of stem cell research & therapy, 4(9), 2-2 (2012)
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Frontiers in Pharmacology, 10(9), 634-634 (2019)
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Endocrinology, 156(10), 3791-3803 (2015)
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What is the storage stability of aliquots [1mM] at -80°C?
1 answer-
Helpful?
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What is the molecular weight (MW) of progesterone? How should I account for the fact that the compound contains approximately 70 mg of progesterone per gram, with the remainder being methyl-β-cyclodextrin? How many milligrams of this mixture do I need
1 answer-
The molecular weight for the compound progesterone is 314.46 g/mole. When calculating molar (e.g., :M, mM, etc.) solutions, the molecular weight of
the cyclodextrin component of the complex is typically disregarded, and the solution is prepared considering the amount of the hormone in the preparation and its respective molecular weight. The lot specific certificate of analysis can be reviewed to determine the mg of progesterone present in the solid. This value can then be converted to a mole value with the molecular weight and the solution volume being adjusted to reach the desired concentration.Helpful?
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How long can it be stored as 1mM solution at -20?
1 answer-
Progesterone-Water Soluble (P7556) can be stored in aliquots at -20 C for 6 months. Avoid repeated freeze thaws.
Helpful?
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