The solubility of Progesterone in water is very low. For in vivo studies, the solubility of PROGESTERONE is 0.02 mg/ml in water and 39 mg/ml in H5784 (45% w/v 2-Hydroxypropyl-β-cyclodextrin). We do not run any in vivo studies with any of our chemicals. To use in animal studies, it is recommended to use the Cell culture tested product and also screen lots. P6149 and P8783 are the cell culture tested product numbers, and PHR1142 is a reference standard.
P8783
Progesterone
powder, BioReagent, suitable for cell culture
Sinónimos:
4-Pregnene-3,20-dione
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About This Item
Fórmula empírica (notación de Hill):
C21H30O2
Número de CAS:
Peso molecular:
314.46
Beilstein:
1915950
Número CE:
Número MDL:
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
NACRES:
NA.77
origen biológico:
synthetic (organic)
Formulario:
powder
Ensayo:
≥99%
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
origen biológico
synthetic (organic)
Nivel de calidad
descripción
synthesized from materials derived from plant source
Línea del producto
BioReagent
Ensayo
≥99%
Formulario
powder
potencia
0.1-20 ng/mL
técnicas
cell culture | mammalian: suitable
mp
128-132 °C (lit.)
solubilidad
absolute ethanol: 1 mg/mL
temp. de almacenamiento
room temp
cadena SMILES
CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
Clave InChI
RJKFOVLPORLFTN-LEKSSAKUSA-N
Información sobre el gen
human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)
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Descripción general
Progesterone is a steroid hormone secreted by the ovaries.[1]
Aplicación
Progesterone has been used:
- as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture[2]
- to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model[3]
- as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells[4]
Use in cell culture applications to study sterol regulation of cell signaling and gene expression.
Acciones bioquímicas o fisiológicas
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.
Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy.[5] It is known to prevent preterm delivery, when administered intramuscularly.[6] Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.[7]
Otras notas
Steroid hormone produced by the corpus luteum.
Forma física
powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Reconstitución
To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Carc. 2 - Lact. - Repr. 1A
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Certificados de análisis (COA)
Lot/Batch Number
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Los clientes también vieron
Peroxisome proliferator-activated receptor-? activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents
A.K.G.Kadegowda, et al.
Journal of Dairy Science, 92, 276-4289 (2009)
Clinical Reproductive Medicine and Surgery, 84(7), 17-17 (2007)
Neonatal progesterone programs adult uterine responses to progesterone and susceptibility to uterine dysfunction
Dhakal P, et al.
Endocrinology, 156(10), 3791-3803 (2015)
Internalization of coxsackievirus A9 is mediated by beta2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin
Heikkila O, et al.
Journal of Virology, 84(7), 3666-3681 (2010)
Efficacy of progesterone following a moderate unilateral cortical contusion injury
Gilmer LK, et al.
Journal of Neurotrauma, 25(6), 593-602 (2008)
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How can a 10mg/ml stock solution of PHR1142 be prepared for injection into a mouse?
1 answer-
Helpful?
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What is the appropriate method for reconstituting item P8783, Progesterone?
1 answer-
Progesterone dissolves in DMSO to 100 mM and in ethanol to 100 mM.
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