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Key Documents

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E3638

Sigma-Aldrich

Estazolam

Sinónimos:

8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

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About This Item

Fórmula lineal:
C16H11N4Cl
Número de CAS:
29975-16-4
Peso molecular:
294.74
EC Number:
249-982-4
MDL number:
MFCD00867537
UNSPSC Code:
12352200
PubChem Substance ID:
24894524
NACRES:
NA.77

Quality Level

200

drug control

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

originator

Abbott

SMILES string

Clc1ccc-2c(c1)C(=NCc3nncn-23)c4ccccc4

InChI

1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2

InChI key

CDCHDCWJMGXXRH-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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Biochem/physiol Actions

Hypnotic; ligand for the GABAA receptor benzodiazepine modulatory site.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Alprazolam solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

A-903

Alprazolam solution

α-Hydroxyalprazolam powder, ≥98% (TLC)

Sigma-Aldrich

H9149

α-Hydroxyalprazolam

Zolpidem ≥98% (HPLC), solid

Sigma-Aldrich

Z103

Zolpidem

Clonazolam solution 1 mg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

Supelco

C-167

Clonazolam solution

Masatomo Miura et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 18(5), 525-528 (2002-05-31)
A high-performance liquid chromatography (HPLC) assay was developed for the determination of estazolam in human plasma. Estazolam and alprazolam as an internal standard were detected by ultraviolet absorbance at 240 nm. Estazolam in plasma was extracted by a rapid and
H Inoue et al.
Forensic science international, 113(1-3), 367-373 (2000-09-09)
Benzodiazepines are one of the most widely prescribed drugs for the treatment of a wide spectrum of clinical disorders. They are used as anticonvulsants, anxiolytics, hypnotics or muscle relaxants with different duration of action. In this paper, a simple and
Yuan Tian et al.
Journal of pharmaceutical and biomedical analysis, 47(4-5), 899-906 (2008-05-13)
A simple, rapid, sensitive and selective liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the quantification of rupatadine in human plasma using estazolam as internal standard (IS). Following liquid-liquid extraction, the analytes were separated using a mobile
Kirkwood, C.K., et al.
Journal of the American Pharmaceutical Association, 39, 688-688 (1999)
Jiu-xi Yuan et al.
Fa yi xue za zhi, 27(2), 117-119 (2011-05-25)
To investigate the stability of estazolam in biological samples preserved in formaldehyde solution. The dog was given intragastric administration of estazolam with a dose of 37.6 mg/kg and killed 2 h later. Heart, liver, kidney and brain of the dog
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