C5851

CGP 35348 hydrate

≥97% (NMR), solid

• Sinónimos: (3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate
• Fórmula empírica (notación de Hill): C₈H₂₀NO₄P · xH₂O
• Número de CAS: 123690-79-9
• Peso molecular: 225.22 (anhydrous basis)
• Número MDL: MFCD11045877
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329775103
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (NMR)
• Formulario: solid
• condiciones de almacenamiento: desiccated
• color: white
• solubilidad: H₂O: >20 mg/mL
• emisor: Novartis
• temp. de almacenamiento: −20°C
• cadena SMILES: O.CCOC(OCC)P(O)(=O)CCCN
• InChI: 1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2
• Clave InChI: SRBHGEXMDCJOMS-UHFFFAOYSA-N

Descripción

Aplicación

CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABA_B) receptor inhibitor:

• to study its effects on intrinsic optical signal (IOS) in rat hippocampus
• alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
• to study its effects on hepatocellular carcinoma cells (HCC)

Acciones bioquímicas o fisiológicas

CGP 35348 is a γ-aminobutyric acid-B (GABA_B) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Precaución

Product is hygroscopic

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)