The stability of this product in DMSO has not been determined. However, various sources recommend storing stock solutions in DMSO at -20°C for 1 month and at -80°C for 1 year. As a general rule, avoid repeated freeze/thaw cycles. This information has not been validated.
PHR1422
Atorvastatin Calcium
Atorvastatin Calcium
Pharmaceutical Secondary Standard; Certified Reference Material
Sinónimos:
Atorvastatin hemicalcium salt sesquihydrate, 1H-Pyrrole-1-heptanoic acid, [R-(R*,R*)]-2-(4-flurophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl], calcium salt (2:1)
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About This Item
Fórmula empírica (notación de Hill):
C66H68CaF2N4O10 · 3H2O
Número de CAS:
Peso molecular:
1209.39
Código UNSPSC:
41116107
NACRES:
NA.24
En este momento no podemos mostrarle ni los precios ni la disponibilidad
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grado
certified reference material
pharmaceutical secondary standard
Nivel de calidad
Agency
traceable to Ph. Eur. Y0001327
traceable to USP 1044516
familia API
atorvastatin
CofA
current certificate can be downloaded
técnicas
HPLC: suitable
gas chromatography (GC): suitable
aplicaciones
pharmaceutical (small molecule)
Formato
neat
temp. de almacenamiento
2-30°C
cadena SMILES
[Ca+2].Fc5ccc(cc5)c6[n](c(c(c6c8ccccc8)C(=O)Nc7ccccc7)C(C)C)CC[C@@H](O)C[C@@H](O)CC(=O)O.Fc1ccc(cc1)c2[n](c(c(c2c4ccccc4)\C(=N\c3ccccc3)\[O-])C(C)C)CC[C@@H](O)C[C@@H](O)CC(=O)[O-].O.O.O
InChI
1S/2C33H35FN2O5.Ca.3H2O/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;3*1H2/q;;+2;;;/p-2/t2*26-,27-;;;;/m11..../s1
Clave InChI
SHZPNDRIDUBNMH-NIJVSVLQSA-L
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Descripción general
Atorvastatin Calcium is a synthetic cholesterol lowering agent,[1] which acts as an inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. It is widely used in combination with amlodipine besylate as a medication in the treatment of vasospastic angina, hypertension, chronic stable angina and primary dysbetalipoproteinemia.[2]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Aplicación
Azathioprine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[2][1] using reversed-phase high-performance liquid chromatography (RP-HPLC)[2] and spectrophotometric techniques.[1]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Nota de análisis
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Otras notas
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Nota al pie de página
To see an example of a Certificate of Analysis for this material enter LRAC0148 in the slot below. This is an example certificate only and may not be the lot that you receive.
Analito
Descripción
Atorvastatin hemicalcium salt sesquihydrate
Producto relacionado
Referencia del producto
Descripción
Precios
columna analítica
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Carc. 2 - Repr. 1B
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Chromatograms
application for HPLC-
I have made a stock solitution in DMSO. At what temperature should I store it and what is the shelf life?
1 answer-
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Buenos días, como debe reconstituirse el producto: Atorvastatin Calcium, PHR1422? Muchas gracias, Aina
1 answer-
The following solubility characteristics are given in the monograph of the European Pharmacopoeia: practically insoluble in water, very slightly soluble to very soluble in ethanol (96 percent), freely soluble to very soluble in methanol, practically insoluble to freely soluble in methylene chloride, and freely soluble in dimethyl sulfoxide.
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