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Merck

D6518

Sigma-Aldrich

Diethylenetriaminepentaacetic acid

≥99% (titration)

Sinónimos:

(Carboxymethylimino)bis(ethylenenitrilo)tetraacetic acid, N,N-Bis(2-[bis(carboxymethyl)amino]ethyl)glycine, DETAPAC, DTPA, Penta(carboxymethyl)diethylenetriamine, Pentetic acid

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About This Item

Fórmula lineal:
[(HOOCCH2)2NCH2CH2]2NCH2COOH
Número de CAS:
Peso molecular:
393.35
Beilstein:
1810219
Número CE:
Número MDL:
Código UNSPSC:
12352106
ID de la sustancia en PubChem:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

synthetic (organic)

Nivel de calidad

Ensayo

≥99% (titration)

Formulario

powder

mp

219-220 °C (lit.)

solubilidad

1 M HCl: 50 mg/mL, clear, colorless

temp. de almacenamiento

room temp

cadena SMILES

OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O

InChI

1S/C14H23N3O10/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27)

Clave InChI

QPCDCPDFJACHGM-UHFFFAOYSA-N

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Descripción general

Diethylenetriaminepentaacetic acid is a diethylenetriaminepentaacetic anhydride, which is a bifunctional chelating agent.[1] It is used for the treatment of poisoning.[2]

Aplicación

Diethylenetriaminepentaacetic acid has been used:
  • for cofilin activity assay[3]
  • to determine the specificity of superoxide in the transverse aortic constriction (TAC) hearts[4]
  • for Europium bead-based detection assays[5]
  • to detect reduced (S- active) or irreversibly oxidized (SO3H inactive) tyrosine-protein phosphatase non-receptor type 6 (SHP-1) in thymocytes[6]

Nota de preparación

Purified

Pictogramas

Health hazardExclamation mark

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation

Órganos de actuación

Respiratory Tract

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

392.0 °F - closed cup

Punto de inflamabilidad (°C)

200 °C - closed cup


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Visite la Librería de documentos

Highly stable lyophilized homogeneous bead-based immunoassays for on-site detection of bio warfare agents from complex matrices
Mechaly A, et al.
Analytical Chemistry, 88(12), 6283-6291 (2016)
Detection of Intracellular Reduced (Catalytically Active) SHP-1 and Analyses of Catalytically Inactive SHP-1 after Oxidation by Pervanadate or H2O2
Choi S and Love PE
Bio-protocol, 8(1) (2018)
Bioconjugate Techniques (2013)
Paraoxonase 2 prevents the development of heart failure
Li W, et al.
Free Radical Biology & Medicine, 121, 117-126 (2018)
Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization
Piroli GG, et al.
Molecular and Cellular Proteomics, mcp-RA118 (2018)

Questions

1–6 of 6 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What cations can be chelated with Product D6518, Diethylenetriaminepentaacetic acid (DTPA)?

    1 answer
    1. DTPA forms stable complexes with most divalent and trivalent cations.  Some examples are Fe3+, Cu2+, Ni2+, Pb2+, Zn2+, Fe2+, Mn2+, Ca2+,  Mg2+, and Ba2+.

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  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  5. What are the pKa values for Product D6518, Diethylenetriaminepentaacetic acid?

    1 answer
    1. The pKa values for the carboxyl groups as reported in the reference book "Data for Biochemical Research, 3rd ed., page 402, Oxford University Press, New York (1986)." are 1.8, 2.6, 4.4, 8.8, and 10.4.

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  6. How can I get Product D6518, Diethylenetriaminepentaacetic acid, to dissolve?

    1 answer
    1. As is the case with other chelating agents such as EDTA and EGTA, the solubility of DTPA is a function of pH.  Therefore, this compound can be solubilized with either the addition of acid such as a hydrochloric acid solution or (more likely) base such as a sodium hydroxide solution .

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