658548

AG 1478

InSolution, ≥98%, inhibitor EGF receptor tyrosine kinase

• Sinónimos: InSolution AG 1478
• Fórmula empírica (notación de Hill): C₁₆H₁₄ClN₃O₂
• Número de CAS: 175178-82-2
• Peso molecular: 315.75
• MDL number: MFCD00270914
• UNSPSC Code: 12352200
• NACRES: NA.32

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: clearfaint tan
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
• InChI key: GFNNBHLJANVSQV-UHFFFAOYSA-N

Descripción

General description

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC₅₀ = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC₅₀ >100 µM), the platelet-derived growth factor (PDGF) receptor (IC₅₀ >100 µM), and p210^Bcr-Abl (IC₅₀ >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Epidermal growth factor receptor kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 3 nM against of epidermal growth factor receptor kinase

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Levitski, A., and Gazit, A. 1995. Science267, 1782.
Fry, D.W., et al. 1994. Science265, 1093.
Osherov, N., and Levitski, A. 1994. Eur. J. Biochem.225, 1047.
Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

Legal Information

Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: 188.6 °F - closed cup - (Dimethylsulfoxide)
• flash_point_c: 87 °C - closed cup - (Dimethylsulfoxide)