569406

Stearoyl-CoA Desaturase 1 Inhibitor, MF-438

Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3 nM).

• Sinónimos: Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, 2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole
• Fórmula empírica (notación de Hill): C₁₉H₁₈F₃N₅OS
• Peso molecular: 421.44
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥99% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Descripción

General description

A cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC₅₀ of 2.3 nM. In vivo, it exhibits an ED₅₀ of 1-3 mg/kg, p.o., in mouse liver PD assays.

Warning

Toxicity: Standard Handling (A)

Other Notes

Leger, S., et al. 2010. Bioorg Med Chem Lett.2, 499.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable