108975

Leupeptin, Hemisulfate, Microbial

Leupeptin hemisulfate, CAS 103476-89-7, is a reversible inhibitor of trypsin-like proteases and cysteine proteases

• Sinónimos: Leupeptin, Hemisulfate, Microbial, Ac-LLR-CHO, ½H₂SO₄
• Fórmula empírica (notación de Hill): C₂₀H₃₈N₆O₄ · 0.5H₂SO₄
• Número de CAS: 103476-89-7
• Peso molecular: 475.59
• Número MDL: MFCD00037012
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• descripción: Merck USA index - 14, 5456
• Ensayo: ≥90% (HPLC)
• Formulario: lyophilized solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: [N+H](=C(N)N)CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O
• InChI: 1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1
• Clave InChI: GDBQQVLCIARPGH-ULQDDVLXSA-O

Descripción

Descripción general

A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV⁺ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
trypsin- and cysteine-like proteases

Product does not compete with ATP.

Reversible: yes

Advertencia

Toxicity: Standard Handling (A)

Secuencia

Ac-Leu-Leu-arginal, hemisulfate

Reconstitución

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Otras notas

Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
Sarin, A., et al. 1994. J. Immunol.153, 862.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable