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Key Documents

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W381101

Sigma-Aldrich

Neohesperidin dihydrochalcone

≥96%, FG

Sinónimos:

1-(4-((2-O-[6-Deoxy-α-L-mannopyranosyl]-β-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone, NHDC

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About This Item

Fórmula empírica (notación de Hill):
C28H36O15
Número de CAS:
20702-77-6
Peso molecular:
612.58
FEMA Number:
3811
EC Number:
243-978-6
MDL number:
MFCD00017711
UNSPSC Code:
12164502
PubChem Substance ID:
24901889
Flavis number:
16.061
E Number:
E 959
NACRES:
NA.21

biological source

synthetic

Quality Level

400

grade

FG
Fragrance grade
Halal
Kosher

agency

follows IFRA guidelines

reg. compliance

EU Regulation 1223/2009
EU Regulation 1334/2008 & 872/2012

assay

≥96%

mp

156-158 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

organoleptic

odorless

storage temp.

2-8°C

SMILES string

COc1ccc(CCC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)cc2O)cc1O

InChI

1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1

InChI key

ITVGXXMINPYUHD-CUVHLRMHSA-N

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General description

Neohesperidin dihydrochalcone is mainly used as a sweetener and flavoring agent. It can be prepared by the hydrogenation of neohesperidin, a bitter flavonone found in citrus fruits.

Application

  • Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts.: This study explores the molecular mechanisms behind the immunomodulatory effects of Neohesperidin dihydrochalcone, revealing its potential to mitigate endotoxin-induced inflammatory responses (Xia et al., 2015).

    • pictograms

    Exclamation mark
    GHS07

    signalword

    Warning

    hcodes

    H302

    Hazard Classifications

    Acute Tox. 4 Oral

    Storage Class

    11 - Combustible Solids

    wgk_germany

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    ppe

    Eyeshields, Gloves, type N95 (US)

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    Alternative Sweeteners, 87-104 null
    Neohesperidin dihydrochalcone; an updated review on a naturally derived sweetener and flavor potentiator.
    Pratter PJ
    Perfumer & Flavorist (1980)
    M Naim et al.
    Physiology & behavior, 28(6), 979-986 (1982-06-01)
    Preference-aversion behavior to solutions containing neohesperidin dihydrochalcone (NHDHC) was studied rats and baboon monkeys. Electrophysiological responses evoked by application of NHDHC solutions to taste receptors innervated by the chorda tympani and the glossopharyngeal nerves were also measured. As a group
    J H Kroeze
    Chemical senses, 25(5), 555-559 (2000-10-04)
    Neohesperidin dihydrochalcone (NHDC) is an intensive sweetener, obtained by alkaline hydrogenation of neohesperidin. In this investigation a supposed taste enhancing effect of this substance was tested. A three-step procedure was used. In the first experiment, using a pool of 31
    R K Sahu et al.
    Mutation research, 89(1), 69-74 (1981-05-01)
    4 important flavonoid compounds, namely quercetin, kaempferol, neohesperidin dihydrochalcone and rutin, were administered to male mice for the detection of gross chromosomal anomalies by the micronucleus test. The first 3 compounds were positively clastogenic to different extents, whereas the 4th
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