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185892

Sigma-Aldrich

Ethyl chloroformate

97%

Sinónimos:

Chloroformic acid ethyl ester

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About This Item

Fórmula lineal:
ClCOOC2H5
Número de CAS:
541-41-3
Peso molecular:
108.52
Beilstein:
385653
Número CE:
208-778-5
Número MDL:
MFCD00000644
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
24851187
NACRES:
NA.22
En este momento no podemos mostrarle ni los precios ni la disponibilidad

densidad de vapor

3.74 (vs air)

Nivel de calidad

200

presión de vapor

3.42 psi ( 20 °C)

Ensayo

97%

Formulario

liquid

temp. de autoignición

842 °F

índice de refracción

n20/D 1.395 (lit.)

bp

93 °C (lit.)

mp

−81 °C (lit.)

solubilidad

alcohol: miscible
benzene: miscible
chloroform: miscible
diethyl ether: miscible
water: insoluble

densidad

1.135 g/mL at 25 °C (lit.)

grupo funcional

chloro

cadena SMILES

CCOC(Cl)=O

InChI

1S/C3H5ClO2/c1-2-6-3(4)5/h2H2,1H3

Clave InChI

RIFGWPKJUGCATF-UHFFFAOYSA-N

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Aplicación

  • Ethyl chloroformate was used in the synthesis of nitrile oxides[1].
  • It was used as derivatization reagent to investigate stereochemical conversion of chiral non-steroidal anti-inflammatory drugs during derivatization reaction[2].
  • It was used to develop flexible template strategy for the generation of nanometer-scale templates via dip-pen nanolithography[3].
  • It was used as derivatization reagent in an enantiomeric analysis of amino acids by two-dimensional gas chromatography[4].
  • It was also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles[5].

Envase

Derivatization reagent employed in an enantiomeric analysis of amino acids by two-dimensional gas chromatography.[4] Also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.[5]

Palabra de señalización

Danger

Frases de peligro

H225,H290,H302,H314,H330

Clasificaciones de peligro

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

60.8 °F

Punto de inflamabilidad (°C)

16 °C

Equipo de protección personal

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
BCCL3605
MKCW9129
MKCW8445
0000379777
MKCS7882

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M R Wright et al.
Journal of chromatography, 616(1), 59-65 (1993-06-23)
A potential problem with chiral derivatization is the possibility of stereochemical conversion during the derivatization reaction. This possibility has been examined using the non-steroidal anti-inflammatory drugs ibuprofen, ketoprofen, etodolac and flurbiprofen. To avoid possible interference from stereochemical impurities, male Sprague-Dawley
Melanie Junge et al.
Chirality, 19(3), 228-234 (2007-01-19)
The chiral separation of amino acids (AA) derivatised with ethyl chloroformate by using comprehensive two-dimensional gas chromatography is reported. A commercially available enantioselective capillary column (Chirasil-l-Val) has been tested as first-dimension column. Two nonenantioselective stationary phases (BPX50 and BP1) with
Sezin Erarpat et al.
Journal of separation science, 43(6), 1100-1106 (2019-12-21)
A green and fast analytical method for the determination of l-methionine in human plasma is presented in this study. Preconcentration of the analyte was carried out by switchable solvent liquid phase microextraction after ethyl chloroformate derivatization reaction. Instrumental detection of
Tetrahedron Letters, 48, 1465-1465 (2007)
A convenient preparative method of nitrile oxides by the dehydration of primary nitro compounds with ethyl chloroformate or benzenesulfonyl chloride in the presence of triethylamine.
Shimizu T, et al.
Bulletin of the Chemical Society of Japan, 59(9), 2827-2831 (1986)
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Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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