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126462

Sigma-Aldrich

6,7-Dimethyl-2,3-di(2-pyridyl)quinoxaline

98%

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About This Item

Fórmula empírica (notación de Hill):
C20H16N4
Número de CAS:
6627-38-9
Peso molecular:
312.37
EC Number:
229-592-0
MDL number:
MFCD00006730
UNSPSC Code:
12352100
PubChem Substance ID:
24847727
NACRES:
NA.22

assay

98%

form

powder

mp

191-193 °C (lit.)

SMILES string

Cc1cc2nc(-c3ccccn3)c(nc2cc1C)-c4ccccn4

InChI

1S/C20H16N4/c1-13-11-17-18(12-14(13)2)24-20(16-8-4-6-10-22-16)19(23-17)15-7-3-5-9-21-15/h3-12H,1-2H3

InChI key

NACXMBPTPBZQHY-UHFFFAOYSA-N

Categorías relacionadas

Application

6,7-Dimethyl-2,3-di-(2-pyridyl)quinoxaline has been used as an internal standard to investigate the clinical pharmacokinetics of nelfinavir mesylate, a potent inhibitor of HIV-1 protease.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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E Y Wu et al.
Journal of chromatography. B, Biomedical sciences and applications, 695(2), 373-380 (1997-08-01)
Nelfinavir mesylate, a potent and orally bioavailable inhibitor of HIV-1 protease (Ki=2 nM), has undergone Phase III clinical evaluation in a large population of HIV-positive patients. A high-performance liquid chromatography analytical method was developed to determine the pharmacokinetic parameters of
B Louveau et al.
Biomedical chromatography : BMC, 30(12), 2009-2015 (2016-06-10)
A precise and accurate high-performance liquid chromatography (HPLC) quantification method of rifampicin in human plasma was developed and validated using ultraviolet detection after an automatized solid-phase extraction. The method was validated with respect to selectivity, extraction recovery, linearity, intra- and
Salmaan Kanji et al.
Clinical pharmacokinetics, 59(3), 327-334 (2019-09-01)
Sustained low-efficiency dialysis (SLED) is a hybrid form of dialysis that is increasingly used in critically ill patients with kidney injury and hemodynamic instability. Antimicrobial dosing for patients receiving SLED is informed by pharmacokinetic studies that describe the drug clearance.
Valeria Avataneo et al.
The Journal of antimicrobial chemotherapy, 75(7), 1772-1777 (2020-05-04)
Remdesivir has received significant attention for its potential application in the treatment of COVID-19, caused by SARS-CoV-2. Remdesivir has already been tested for Ebola virus disease treatment and found to have activity against SARS and MERS coronaviruses. The remdesivir core
Sara Baldelli et al.
Therapeutic drug monitoring, 36(6), 739-745 (2014-04-18)
Recently, the European Medicines Agency (EMA) has released new guidelines on the validation of bioanalytical methods. In this work, we compared the analytical performance of 2 high-performance liquid chromatography with tandem mass spectrometry methods designed for the quantification of the

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