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B7639

Sigma-Aldrich

(+)-Biotin hydrazide

≥97% (TLC), powder

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100 MG
$183.00
1 G
$1,150.00

$183.00

Estimated to ship on04 April 2025

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100 MG
$183.00
1 G
$1,150.00

About This Item

Empirical Formula (Hill Notation):
C10H18N4O2S
CAS Number:
66640-86-6
Molecular Weight:
258.34
Beilstein:
28347
MDL number:
MFCD00078532
UNSPSC Code:
12352203
PubChem Substance ID:
24892012
NACRES:
NA.46

$183.00

Estimated to ship on04 April 2025

Request a Bulk Order

Quality Level

200

Assay

≥97% (TLC)

form

powder

solubility

DMSO: ≤20 mg/mL

storage temp.

2-8°C

SMILES string

[H][C@]12CS[C@@H](CCCCC(=O)NN)[C@@]1([H])NC(=O)N2

InChI

1S/C10H18N4O2S/c11-14-8(15)4-2-1-3-7-9-6(5-17-7)12-10(16)13-9/h6-7,9H,1-5,11H2,(H,14,15)(H2,12,13,16)/t6-,7-,9-/m0/s1

InChI key

KOZWHQPRAOJMBN-ZKWXMUAHSA-N

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General description

Biotin hydrazide is a biotinylation reagent used to biotinylate glycoproteins with their sugar moieties[1]. Biotin hydrazide can be used to prepare biotin-conjugated alginate[2]. It can also be used for covalent attachment to PAAc via carbodi-imide cross linking[3].

Application

(+)-Biotin hydrazide has been used:
  • the modification of alginate[4]
  • for the labelling of mitochondrial proteins from non-muscle tissues[5]
  • as a component of glycoprotein staining solution[6]
  • in periodic acid-biotin-hydrazide (PABH) assay for mucins[7]
  • for labeling surface functional groups, biologically active molecules such as antibodies, lectins, sugars, nucleic acids or molecules with free carboxylic or keto groups.
  • for coupling to glycoproteins through the carbohydrate by hydrazone formation

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000395005
0000395004
0000346180
0000332325
0000295062

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Boris Polyak et al.
Biomacromolecules, 5(2), 389-396 (2004-03-09)
Biotin was covalently coupled with alginate in an aqueous-phase reaction by means of carbodiimide-mediated activation chemistry to provide a biotin-alginate conjugate for subsequent use in biosensor applications. The synthetic procedure was optimized with respect to pH of the reaction medium
Studying mucin secretion from human bronchial epithelial cell primary cultures
Mucins, 259-277 (2012)
Kazumi Ninomiya et al.
Nutrients, 10(10) (2018-10-18)
Inhibiting starch hydrolysis into sugar could reduce postprandial blood glucose elevation and contribute to diabetes prevention. Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it
E P Diamandis et al.
Clinical chemistry, 37(5), 625-636 (1991-05-01)
The biotin-(strept)avidin system has been used for many years in a variety of different applications. Here we present a general overview of the system, describe its components and advantages, and show how the system is used in various applications, with
Jinzi Wu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1019, 128-131 (2015-11-23)
Protein carbonyls are protein oxidation products that are often used to measure the magnitude of protein oxidative damage induced by reactive oxygen or reactive nitrogen species. Protein carbonyls have been found to be elevated during aging and in age-related diseases
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