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About This Item
Empirical Formula (Hill Notation):
C120H182N38O43S6
CAS Number:
Molecular Weight:
3037.35
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32
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Quality Level
Assay
≥97% (HPLC)
form
powder
composition
Peptide content, ~70%
storage temp.
−20°C
Gene Information
human ... CACNA1B(774)
mouse ... CACNA1B(12287)
rat ... CACNA1B(257648)
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Amino Acid Sequence
Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 [Disulfide Bridges: 1-16, 8-19, 15-26]
Application
ω-Conotoxin GVIA has been used as an antagonist for N-type calcium channel (CaV2.2) in various studies.
Powerful probe for exploring the vertebrate pre-synaptic terminal.
Biochem/physiol Actions
ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities.
Blocks specific voltage-dependent N-type Ca2+ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Precursor structure of omega-conotoxin GVIA determined from a cDNA clone
Colledge CJ, et al.
Toxicon, 30(9), 1111-1116 (1992)
Crotoxin from Crotalus durissus terrificus snake venom induces the release of glutamate from cerebrocortical synaptosomes via N and P/Q calcium channels
da Silva Lomeo R, et al.
Toxicon, 85(1), 5-16 (2014)
Inhibition of central neurotransmitter release by omega-conotoxin GVIA, a peptide modulator of the N-type voltage-sensitive calcium channel
Dooley DJ, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 336(4), 467-470 (1987)
CaV2. 2 gates calcium-independent but voltage-dependent secretion in mammalian sensory neurons
Chai Z, et al.
Neuron, 96(6), 1317-1326 (2017)
C J Herrero et al.
British journal of pharmacology, 127(6), 1375-1387 (1999-08-24)
Rat alpha3beta4 or alpha7 neuronal nicotinic acetylcholine receptors (AChRs) were expressed in Xenopus laevis oocytes, and the effects of various toxins and non-toxin Ca2+ channel blockers studied. Nicotinic AChR currents were elicited by 1 s pulses of dimethylphenylpiperazinium (DMPP, 100
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