Skip to Content
Merck
All Photos(1)

Documents

810314P

Avanti

NBD Phytosphingosine

Omega-NBD D-ribo-Phytosphingosine, powder

Synonym(s):

(2S,3S,4R)-2-amino-18-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)octadecane-1,3,4-triol

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C24H41N5O6
CAS Number:
2260669-58-5
Molecular Weight:
495.61
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (810314P-100ug)
pkg of 1 × 250 μg (810314P-250ug)
pkg of 1 × 50 μg (810314P-50ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810314P

shipped in

dry ice

storage temp.

−20°C

General description

Phytosphingosine (PHS) is one of the important constituent of phytoceramides. This sphingoid has a hydroxyl group at C-4 of the sphingoid long-chain base. PHS is a component of mammalian epidermis and is widely distributed in fungi and plants. Nitrobenzoxadiazole/7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) is a fluorescent conjugate.

Application

NBD Phytosphingosine has been used as a substrate in ceramide synthase assays.

Biochem/physiol Actions

Phytosphingosine (PHS) is capable of activating G-protein coupled receptor 120 (GPR120). Treating cultured keratinocytes (KC) with PHS can enhance the content of ceramide NP. It plays as key role in epidermal differentiation and also possesses anti-inflammatory and antimicrobial activities.

Packaging

5 mL Amber Glass Screw Cap Vial (810314P-100ug)
5 mL Amber Glass Screw Cap Vial (810314P-250ug)
5 mL Amber Glass Screw Cap Vial (810314P-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Phytosphingosine is a novel activator of GPR120
Nagasawa T, et al.
Test, 164(1), 27-32 (2018)
The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans
Munshi MA, et al.
Testing, 22(6), 1392-1400 (2018)
Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes
Choi HK, et al.
Lipids, 53(9), 909-918 (2018)
Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin
Kim S, et al.
Molecular Medicine, 12(1), 17-24 (2006)
Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation
Choi H K, et al.
Archives of Dermatological Research, 309(10), 795-803 (2017)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service