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SML3553

Sigma-Aldrich

STF-1084

≥98% (HPLC)

Synonym(s):

ENPP1 inhibitor Compound 15, P-​[2-​[1-​(6,​7-​dimethoxy-​4-​quinazolinyl)​-​4-​piperidinyl]​ethyl]​-phosphonic acid

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5 MG
€76.40
25 MG
€308.00

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5 MG
€76.40
25 MG
€308.00

About This Item

Empirical Formula (Hill Notation):
C17H24N3O5P
CAS Number:
2298390-71-1
Molecular Weight:
381.36
UNSPSC Code:
12352200
NACRES:
NA.77

€76.40

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=P(O)(O)CCC(CC1)CCN1C2=NC=NC3=C2C=C(OC)C(OC)=C3

InChI

1S/C17H24N3O5P/c1-24-15-9-13-14(10-16(15)25-2)18-11-19-17(13)20-6-3-12(4-7-20)5-8-26(21,22)23/h9-12H,3-8H2,1-2H3,(H2,21,22,23)

InChI key

SNLWMWQNJTVWKD-UHFFFAOYSA-N

Biochem/physiol Actions

Cell-impermeable, potent, selective, stable and nontoxic competitive inhibitor of ENPP1 that inhibit degradation of extracellular cGAMP under physiological conditions
STF-1084 (ENPP1 inhibitor Compound 15) Is a cell-impermeable, potent, selective, stable and nontoxic competitive inhibitor of ENPP1 (ectonucleotide pyrophosphatase phosphodiesterase 1) that inhibit degradation of extracellular cGAMP under physiological conditions. STF-1084 had no effect on intracellular cGAMP. STF-1084 synergized with IR to significantly delay tumor progression in three triple-negative breast cancer cell lines 4T1-luc mice model.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity
Nature cancer, 1, 184-196 (2020)
32726585
Cell Chemical Biology, 27, 1347-1358 (2020)

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