Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

SML2787

Sigma-Aldrich

DJ001 (E/Z)

≥98% (HPLC)

Synonym(s):

(2E/Z)-3-[(3-Nitrophenyl)amino]-1-phenyl-2-propen-1-one, (E/Z)-3-((3-nitrophenyl)amino)-1-phenylprop-2-en-1-one, (E/Z)-3-(3-Nitrophenylamino)-1-phenylprop-2-en-1-one, (E/Z)-DJ001, Compound 3071, Compound 5483071

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
€82.40
25 MG
€267.00

€82.40

Please contact Customer Service for Availability
All Photos(1)

Select a Size

Change View
5 MG
€82.40
25 MG
€267.00

About This Item

Empirical Formula (Hill Notation):
C15H12N2O3
CAS Number:
15753-65-8
Molecular Weight:
268.27
UNSPSC Code:
51111800
NACRES:
NA.77

€82.40

Please contact Customer Service for Availability

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C1)/C=C\NC2=CC=CC([N+]([O-])=O)=C2

InChI

1S/C15H12N2O3/c18-15(12-5-2-1-3-6-12)9-10-16-13-7-4-8-14(11-13)17(19)20/h1-11,16H/b10-9-

InChI key

OVTJWWUGQKIRCL-KTKRTIGZSA-N

Biochem/physiol Actions

DJ001 is a selective, allosteric and non-competitive receptor protein tyrosine phosphatase-sigma (PTPσ) inhibitor (IC50 = 1.43 μM; >10 μM/20 other phosphatases) that promotes BM hematopoietic stem/progenitor cells (HSPCs) expansion (0.1-1 μg/mL or 0.373-3.73 μM; murine CD34- KSL cells) and suppresses radiation-induced BM HSC apoptosis (1-5 μg/mL; murine KSL & human CD34+ cells) via RhoGTPase/RAC1 activation and BCL-XL induction. DJ001 accelerates hematologic recovery and improves survival of irradiated mice in vivo (5 mg/kg/d s.c.). The (Z)- & (E)-isomers exist in equilibrium in polar solvents with (Z) showing enhanced binding-affinity to PTPσ catalytic & allosteric sites.
Selective, allosteric receptor protein tyrosine phosphatase-sigma (PTPσ) inhibitor that promotes BM hematopoietic stem/progenitor cells (HSPCs) expansion in vitro & in vivo.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Yurun Zhang et al.
Nature communications, 10(1), 3667-3667 (2019-08-16)
Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult neurons and regulates neural regeneration. We recently discovered that PTPσ is also expressed by hematopoietic stem cells (HSCs). Here, we describe small molecule inhibitors of PTPσ that promote HSC regeneration

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service