The GRIN2A (glutamate ionotropic receptor NMDA (N-methyl-D-aspartate) type subunit 2A) gene is mapped to human chromosome 16p13.2. It codes for a transmembrane ligand-gated ion channel called N-methyl-D-aspartate glutamate receptor α2 subunit.
Immunogen
Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A
Biochem/physiol Actions
The GRIN2A (glutamate ionotropic receptor NMDA (N-methyl-D-aspartate) type subunit 2A) gene is associated with focal epilepsy and impaired speech. NMDA glutamate receptor α2 subunit is involved in neuron development, maintains synaptic plasticity and is associated with memory. GRIN2A is related to schizophrenia and Alzheimer′s disease. Mutations in GRIN2A gene upregulates NMDA action and might lead to melanoma tumors. NMDA participates in apoptosis and proliferation of cancer cells.
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Physical form
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Certificates of Analysis (COA)
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GRIN2A mutations in epilepsy-aphasia spectrum disorders
Yang X, et al.
Brain & Development, 40(3), 205-210 (2018)
Epilepsy in patients with GRIN2A alterations: genetics, neurodevelopment, epileptic phenotype and response to anticonvulsive drugs
von Stupnagel C, et al.
European Journal of Paediatric Neurology, 21(3), 530-541 (2017)
2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor
Gorska PM, et al.
Journal of Cellular Physiology, 232(11), 3030-3049 (2017)
Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency-molecular profiling and functional rescue
Addis L, et al.
Scientific Reports, 7(1), 66-66 (2017)
Selected GRIN2A mutations in melanoma cause oncogenic effects that can be modulated by extracellular glutamate
Dmello SAN, et al.
Cell Calcium, 60(6), 384-395 (2016)
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