Natriuretic peptide receptor 3 (NPR3) is a natriuretic peptide receptor. It is expressed in endothelial cells, vessels, endocrine glands, lungs and kidneys. The gene encoding NPR3 is localized on human chromosome 5p14-p13. The protein consists of a 450-amino acid extracellular ligand-binding domain, a transmembrane region and a cytoplasmic tail.
Immunogen
Peptide with sequence C-HRELREDSIRSHFS, from the C-terminal region of the protein sequence according toNP_000899.1
Application
Anti-NPR3 (C-terminal) antibody produced in goat has been used in Western blotting.
Biochem/physiol Actions
Natriuretic peptide receptor 3 (NPR3) has a role in the clearance of natriuretic peptides and modulates their plasma levels. It is associated with essential hypertension. NPR3 may be involved in signaling pathways and is associated with inhibitory G protein.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and pressure in mammals. It is still unclear whether ANP controls cold-induced thermogenesis in vivo. Here, we show that acute cold exposure induces cardiac ANP secretion in mice and humans.
NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study.
Hu Q
Oncotarget (2016)
Association of NPRA and NPRC gene variants and hypertension in Mongolian population.
International journal of obesity (2005), 40(4), 714-720 (2015-10-27)
Catecholamines and natriuretic peptides (NPs) are the only hormones with pronounced lipolytic effects in human white adipose tissue. Although catecholamine-induced lipolysis is well known to be impaired in obesity and insulin resistance, it is not known whether the effect of
Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation.
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