SAB1407309
Anti-FGF21 antibody produced in mouse
purified immunoglobulin, buffered aqueous solution
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50 μG
€417.00
€417.00
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50 μG
€417.00
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
€417.00
Please contact Customer Service for Availability
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~22.3 kDa
species reactivity
human, rat
technique(s)
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FGF21(26291)
General description
FGF (fibroblast growth factor) family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. The gene is mapped to human chromosome 19q13.33 and codes for a member of FGF superfamily. The encoded protein is produced in liver.
Immunogen
FGF21 (AAH18404.1, 1 a.a. ~ 209 a.a) full-length human protein.
Sequence
MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS
Sequence
MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS
Biochem/physiol Actions
The members of FGF (fibroblast growth factor) family take part in cell survival and mitogenic activities. FGFs are associated with a number of physiological processes such as cell growth, morphogenesis, embryonic development, tissue repair, tumor growth and invasion. FGF21 is a hormonal factor that regulates glucose homeostasis and energy metabolism. It possesses anti-diabetic properties by mediating glucose uptake in peripheral tissues. It also exhibits autocrine effects in white adipose tissue. FGF21 is present in milk and is needed for intestinal function in the neonate. It is also associated with bone loss. FGF21 is considered hepatoprotective in nature.
Physical form
Solution in phosphate buffered saline, pH 7.4
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Novel locus including FGF21 is associated with dietary macronutrient intake.
Chu A Y, et al.
Human Molecular Genetics, 22(9), 1895-1902 (2013)
Growth factors and chondrogenic differentiation of mesenchymal stem cells.
Danisovic L, et al.
Tissue & cell, 44(2), 69-73 (2012)
A liver-bone endocrine relay by IGFBP1 promotes osteoclastogenesis and mediates FGF21-induced bone resorption.
Wang X, et al.
Cell Metabolism, 22(5), 811-824 (2015)
Human FGF-21 is a substrate of fibroblast activation protein.
Coppage A L, et al.
PLoS ONE, 11(3), e0151269-e0151269 (2016)
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
Dunshee DR
The Journal of Biological Chemistry, 291, 5986-5996 (2016)
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