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This product is soluble in water at 50 mg/mL. Solutions may be filter sterilized and are stable for 2 weeks at 2-8 °C. Solutions should be protected from light.
See the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/716/505/f0503pis.pdf
F0503
5-Fluoro-2′-deoxyuridine
thymidylate synthase inhibitor
Synonym(s):
floxuridine, 2′-Deoxy-5-fluorouridine, FUDR, Floxuridine
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100 MG
€289.00
250 MG
€687.00
1 G
€1,790.00
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100 MG
€289.00
250 MG
€687.00
1 G
€1,790.00
About This Item
Empirical Formula (Hill Notation):
C9H11FN2O5
CAS Number:
Molecular Weight:
246.19
Beilstein:
90221
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
biological source
synthetic (organic)
Quality Level
Assay
≥99% (HPLC)
form
powder
mp
148 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
room temp
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O
InChI
1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key
ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Gene Information
human ... TYMS(7298)
mouse ... Tyms(22171)
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General description
5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells.[1] Floxuridine is effective for treating liver cancer[2] and eliminating virulence of Staphylococcus aureus.[3] Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity.[4] Floxuridine is effective on solid tumours and advanced stage cancers.[5]
Application
Biochem/physiol Actions
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Is it possible to sterile filter (0.2 mikrometer) this compound for safer use in cell culture?
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