E4642

(±)-Epinephrine hydrochloride

≥98% (TLC), powder, adrenergic receptor agonist

• Synonym(s): (±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
• Empirical Formula (Hill Notation): C₉H₁₃NO₃ · HCl
• CAS Number: 329-63-5
• Molecular Weight: 219.67
• EC Number: 206-346-0
• MDL number: MFCD00050562
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278422
• NACRES: NA.77

Properties

• Product Name: (±)-Epinephrine hydrochloride,
• Quality Level: 200
• solubility: H₂O: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(CNC)C1=CC=C(O)C(O)=C1.Cl
• InChI: 1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
• InChI key: ATADHKWKHYVBTJ-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

Description

General description

Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system.[1] It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors.[2] Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.[3]

Application

(±)-Epinephrine hydrochloride has been used:

• in the induction of renalase expression in Human renal proximal tubular epithelial cells[4]
• in the infusion studies to test its effect on heart rate and eye temperature measurements in bull[5]
• as a medium supplement for the stimulation of endothelial progenitor cells[6]

Biochem/physiol Actions

Adrenergic receptor agonist.

Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility.[3] It is used in the treatment of acute anaphylaxis.[7] Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.[8]

Other Notes

The ratio of +/- adrenaline is not determined.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301 + H311,H315,H319,H335
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves