D0162
2′,3′-Dideoxyinosine
≥98% (HPLC)
Synonym(s):
ddI, ddIno
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C10H12N4O3
CAS Number:
Molecular Weight:
236.23
Beilstein:
3619529
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.55
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Quality Level
Assay
≥98% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC=Nc23
InChI
1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
InChI key
BXZVVICBKDXVGW-NKWVEPMBSA-N
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Biochem/physiol Actions
Nucleotide antagonist
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Elizabeth Ojewole et al.
Planta medica, 78(4), 354-361 (2011-12-14)
The buccal mucosal route offers several advantages but the delivery of certain drugs can be limited by low membrane permeability. This study investigated the buccal permeability properties of didanosine (ddI) and assessed the potential of Aloe vera gel (AVgel) as
Jan Balzarini et al.
European journal of medicinal chemistry, 44(1), 303-311 (2008-04-19)
A series of novel thiazolidin-4-ones bearing a lipophilic adamantyl substituent at position 2 or 3 were synthesized. A majority of them showed a modest anti-HIV-1 activity, whereas 2-adamantan-1-yl-3-(4,6-dimethylpyrimidin-2-yl)-thiazolidin-4-one (8) was endowed with a remarkable antiviral potency (EC(50)=0.67 microM). The new
Yuan-Zhen Xiong et al.
European journal of medicinal chemistry, 43(6), 1230-1236 (2007-09-18)
A series of novel 6-naphthyloxy substituted DATA analogues bearing different substituents on the C-6 position of triazine ring were synthesized and evaluated for their in vitro anti-HIV activity in MT-4 cells. The results demonstrated that most of the compounds in
Jan Balzarini et al.
European journal of medicinal chemistry, 42(7), 993-1003 (2007-02-27)
A series of novel thiazolidin-4-ones bearing a lipophilic adamantyl substituent at position 2, and versatile substituents on the nitrogen atom of the thiazolidine ring, were synthesized whereas several compounds exhibited a modest anti-HIV-1 activity, (+/-)-2-adamantan-1-yl-3-(4,6-dimethyl-pyridin-2-yl)-thiazolidin-4-one 22 was endowed with a
Ana C Venhoff et al.
Antimicrobial agents and chemotherapy, 53(7), 2748-2751 (2009-05-13)
Fosalvudine tidoxil is a prodrug derived from the nucleoside reverse transcriptase inhibitor 3-deoxy-3-fluorothymidine (FLT; alovudine). FLT effectively inhibits resistant human immunodeficiency virus type 1, but its clinical development was stopped due to bone marrow and liver toxicity. In this study
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