Potency is not a quality specification for the product and, for that reason, is not determined.
A8523
Amoxicillin
95.0-102.0% anhydrous basis
Synonym(s):
Amoxicillin anhydrous, D-(-)-α-Amino-p-hydroxybenzyl penicillin
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1 G
€36.10
5 G
€124.00
25 G
€496.00
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1 G
€36.10
5 G
€124.00
25 G
€496.00
About This Item
Empirical Formula (Hill Notation):
C16H19N3O5S
CAS Number:
Molecular Weight:
365.40
Beilstein:
7507120
EC Number:
MDL number:
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.85
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Quality Level
Assay
95.0-102.0% anhydrous basis
form
powder
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(O)=O
InChI
1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1
InChI key
LSQZJLSUYDQPKJ-NJBDSQKTSA-N
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General description
Chemical structure: ß-lactam
Application
Amoxicillin is used to study the oxygen dependent antimicrobial systems of polymorphonuclear leukocytes (PMNLs), the risk of resistance development in Helicobacter pylori, and various dosing strategies against Streptococcus pneumoniae and Pneumococcal pneumonia [1][2][3][4]. It is also used to study the synthesis of bacterial cell walls at the level of peptidoglycan polymer chain cross-linking involving bacterial transpeptidase.
Biochem/physiol Actions
Amoxicillin is a broad-spectrum, β-lactam antibiotic. It is a 4-hydroxy analog of ampicillin with similar ranges of actions and utility to ampicillin. Amoxicillin inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Customers Also Viewed
José-Manuel Rodríguez-Martínez et al.
Antimicrobial agents and chemotherapy, 53(5), 1766-1771 (2009-03-05)
The characterization of AmpC-type beta-lactamases was performed in a collection of 32 clinical Pseudomonas aeruginosa isolates with intermediate susceptibility or resistance to imipenem and ceftazidime. Twenty-one out of those 32 isolates overexpressed AmpC beta-lactamase, and the MICs of ceftazidime and
Yohei Doi et al.
Antimicrobial agents and chemotherapy, 52(6), 1952-1956 (2008-03-26)
A chromosomally encoded class D beta-lactamase, OXA-114, was characterized from Achromobacter xylosoxidans strain CIP69598. beta-Lactamase OXA-114 shared 56% amino acid identity with the naturally occurring class D beta-lactamase of Burkholderia cenocepacia and 42% identity with the acquired oxacillinases OXA-9 and
Heather K Sun et al.
The Journal of antimicrobial chemotherapy, 56(3), 559-565 (2005-07-19)
Amoxicillin and clarithromycin have been proven to be effective in the treatment of community-acquired pneumonia. This study investigated the in vivo bactericidal efficacy of a novel, pulsatile dosing strategy for amoxicillin and clarithromycin, when used as monotherapy and combination therapy.
Jose-Manuel Rodriguez-Martinez et al.
Antimicrobial agents and chemotherapy, 54(1), 471-476 (2009-11-18)
Two carbapenem-resistant isolates, one Escherichia coli isolate and one Klebsiella pneumoniae isolate, recovered from an Algerian patient expressed a novel VIM-type metallo-beta-lactamase (MBL). The identified bla(VIM-19) gene was located on a ca. 160-kb plasmid and located inside a class 1
M Sörberg et al.
Antimicrobial agents and chemotherapy, 42(5), 1222-1228 (1998-05-21)
We have studied initial killing, morphological alterations, the frequency of occurrence, and the selective growth of resistant subpopulations of Helicobacter pylori during exposure to amoxicillin, clarithromycin, or metronidazole by bioluminescence assay of intracellular ATP levels, microscopy, and a viable count
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Which method do you use to measure the potency?
1 answer-
Helpful?
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Bonjour, je n'ai pas trouvé de fiche pour savoir comment solubiliser à 10 mg/ml de l'amoxicilline A8523 ? Je veux traiter des souris par voie intraperitoneale, et je ne peux pas injecter plus de 100µl. Merci . Catherine
1 answer-
This product is soluble at 50 mg/mL in 1M Ammonium Hydroxide. This stock may then be diluted in a physiologic buffer. This product is not tested for in vivo or in vitro use. Stock solutions would require filter sterilization before use. Also, note that this product tends to have a high moisture content.
It is advised to review the lot-specific Certificate of Analysis to accurately prepare a stock solution.Helpful?
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Solubility?
1 answer-
As mentioned in the product specification sheet, this product can be solubilized in 1 M ammonium hydroxide (50 mg/ml), yielding a clear, colorless to light yellow solution.
Please view the Specification Sheet for more information:
https://www.sigmaaldrich.com/specification-sheets/302/635/A8523-BULK________SIGMA____.pdfHelpful?
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