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90469

Sigma-Aldrich

(RS)-Mevalonic acid lithium salt

≥96.0% (GC)

Synonym(s):

(±)-MVA-Li, rac.-MVA-Li, Lithium (±)-3,5-dihydroxy-3-methyl-pentanoate, Lithium (±)-3,5-dihydroxy-3-methyl-valerate

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10 MG
€122.00
50 MG
€486.00
250 MG
€1,890.00

€122.00


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10 MG
€122.00
50 MG
€486.00
250 MG
€1,890.00

About This Item

Empirical Formula (Hill Notation):
C6H11O4 · xLi+
CAS Number:
Molecular Weight:
147.15 (free acid basis)
MDL number:
UNSPSC Code:
12352107
NACRES:
NA.25
Assay:
≥96.0% (GC)
form:
solid

€122.00


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Request a Bulk Order

Quality Level

Assay

≥96.0% (GC)

form

solid

composition

lithium, 2.2-4.7%

storage temp.

2-8°C

SMILES string

OC(CCO)(CC(=O)O)C

InChI

1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)

InChI key

KJTLQQUUPVSXIM-UHFFFAOYSA-N

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Biochem/physiol Actions

Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Martin Thurnher et al.
Biochimica et biophysica acta, 1831(6), 1009-1015 (2013-03-26)
The mevalonate pathway is a highly conserved metabolic cascade and provides isoprenoid building blocks for the biosynthesis of vital cellular products such as cholesterol or prenyl pyrophosphates that serve as substrates for the posttranslational prenylation of numerous proteins. The pathway
Ai Hosaka et al.
Neurochemical research, 38(3), 589-600 (2012-12-28)
Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been reported to attenuate amyloid-β peptide (Aβ) production in various cellular models. However, the mechanisms by which statins affect neuronal Aβ production have not yet been clarified. Here, we investigated this issue in
Jordi Pérez-Gil et al.
The Biochemical journal, 452(1), 19-25 (2013-04-26)
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including
Adelene Ai-Lian Song et al.
PloS one, 7(12), e52444-e52444 (2013-01-10)
Isoprenoids are a large and diverse group of metabolites with interesting properties such as flavour, fragrance and therapeutic properties. They are produced via two pathways, the mevalonate pathway or the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. While plants are the richest source of
Jianxin Shi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(1), 429-435 (2012-11-28)
Esophageal squamous cell carcinoma (ESCC) is one of the most common lethal tumors in the world. Thus, it is very urgent to develop new therapeutic targets against this disease. The mevalonate (MVA) pathway, paced by its rate-limiting enzyme, hydroxymethylglutaryl coenzyme

Questions

1–2 of 2 Questions  
  1. Is there any information available regarding the solubility of (RS)-Mevalonic acid lithium salt, Catalog 90469, for resuspension purposes?

    1 answer
    1. The solubility of (RS)-Mevalonic acid lithium salt is as follows:
      1. In H2O: 100 mg/mL (648.97 mM; ultrasonic agitation required)
      2.In DMSO: 50 mg/mL (324.49 mM; ultrasonic agitation required)

      Helpful?

  2. What is the recommended solution to dissolve this product in if wanting to add to cell culture media?

    1 answer
    1. This product is not tested for solubility. However various sources state that compound is soluble in water and PBS (may require sonication), as well as DMSO.

      Helpful?

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