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285366

Ethyl 2-(4-chlorophenoxy)-2-methylpropionate

Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropionate
Brand: ALDRICH

99%

Synonym(s):

2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Clofibrate, Ethyl 2-(p-chlorophenoxy)isobutyrate

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₅ClO₃

CAS Number:

637-07-0

Molecular Weight:

242.70

Beilstein:

1913459

MDL number:

MFCD00000615

UNSPSC Code:

12352101

PubChem Substance ID:

329753222

Assay

99%

bp

154-156 °C/20 mmHg (lit.)

density

1.14 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

InChI

1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

InChI key

KNHUKKLJHYUCFP-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

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Probing the fibrate binding specificity of rat liver fatty acid binding protein.

Sara Chuang et al.

Journal of medicinal chemistry, 52(17), 5344-5355 (2009-08-12)

Liver-fatty acid binding protein (L-FABP) is found in high levels in enterocytes and is involved in cytosolic solubilization of fatty acids. In addition, L-FABP has been shown to bind endogenous and exogenous lipophilic compounds, suggesting that it may also play

Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis).

Masayuki Yoshikawa et al.

Journal of natural products, 68(9), 1360-1365 (2005-09-27)

The methanolic extract and its n-butanol-soluble fraction from the flowers of the tea plant (Camellia sinensis) were found to suppress serum triglyceride elevation in olive oil-treated mice. From the n-butanol-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, floratheasaponins A-C (1-3)

Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis.

Toshio Morikawa et al.

Journal of natural products, 71(5), 828-835 (2008-03-28)

The methanolic extract and its saponin fraction (methanol-eluted fraction) of the flowers of Bellis perennis were found to suppress serum triglyceride elevation in olive oil-treated mice. From the saponin fraction, seven new triterpene saponins, perennisosides I (1), II (2), III

Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings.

Leigh V Panlilio et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(8), 1838-1847 (2012-03-29)

Experimental drugs that activate α-type peroxisome proliferator-activated receptors (PPARα) have recently been shown to reduce the rewarding effects of nicotine in animals, but these drugs have not been approved for human use. The fibrates are a class of PPARα-activating medications

PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate.

H M Mehendale

Toxicological sciences : an official journal of the Society of Toxicology, 57(2), 187-190 (2000-09-28)

The article highlighted in this issue is "Peroxisome Proliferator-Activated Receptor Alpha-Null Mice Lack Resistance to Acetaminophen Hepatotoxicity Following Clofibrate Exposure" by Chuan Chen, Gayle E. Hennig, Herbert E. Whiteley, J Christopher Corton, and José E. Manautou (pp. 338-344).

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