LO4100

LOPAC^®1280 - Small Scale

• Synonym(s): Library of Pharmacologically Active Compounds - small scale
• UNSPSC Code: 12352200
• EC Number: 200-664-3
• NACRES: NA.77
• Form: liquid

Properties

• form: liquid
• Quality Segment: 100
• drug control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).

LOPAC^® 1280 is an extensively used library of pharmacologically active compounds. This library includes 1,280 marketed drugs, failed development candidates, and small molecules with well-characterized activities. LOPAC 1280 spans a broad molecular weight range, exhibits multiple mechanisms of action and interacts with a variety of biological receptors.

Application

LOPAC^® 1280 - Small Scale has been used:

• in sprouting assay to screen potential lymphangiogenic inhibitors and the signaling pathways involved in lymphangiogenesis
• for identification of neuroactive compounds by measuring spontaneous activity within single zebrafish embryos by high-content screening assay
• for high-throughput Screen for ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; also known as CD39) and ecto-5′-nucleotidase (CD73) inhibitors

Features and Benefits

Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

• Apoptosis
• G Proteins & Cyclic Nucleotides
• Gene Regulation & Expression
• Ion Channels
• Lipid Signaling
• Multi-Drug Resistance
• Neurotransmission
• Phosphorylation

SDFile provided to construct a database containing:

• Structure
• Primary Name
• Secondary Name
• Pharmacological Activity
• Product Number
• Rack Position

Other Notes

For sale inside of the U.S. only. Customers outside the US should refer to Product Code LO4200.

Legal Information

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS06,GHS08,GHS05,GHS09
• signalword: Danger
• hcodes: H300 + H310 + H330,H314,H317,H334,H340,H350,H360FD,H362,H371,H373,H410
• pcodes: P263 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• flash_point_f: 188.6 °F
• flash_point_c: 87 °C
• wgk: WGK 3