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Sigma-Aldrich

Tetramethyl orthosilicate

98%

Synonym(s):

Tetramethoxysilane

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About This Item

Linear Formula:
Si(OCH3)4
CAS Number:
681-84-5
Molecular Weight:
152.22
Beilstein:
1699658
EC Number:
211-656-4
MDL number:
MFCD00008341
UNSPSC Code:
12352103
PubChem Substance ID:
24853068
NACRES:
NA.23

vapor density

5.25 (vs air)

Quality Level

200

vapor pressure

13 hPa ( 20 °C)

Assay

98%

form

liquid

refractive index

n20/D 1.368 (lit.)

bp

121-122 °C (lit.)

mp

−4 °C (lit.)

density

1.023 g/mL at 25 °C (lit.)

SMILES string

CO[Si](OC)(OC)OC

InChI

1S/C4H12O4Si/c1-5-9(6-2,7-3)8-4/h1-4H3

InChI key

LFQCEHFDDXELDD-UHFFFAOYSA-N

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Application

Tetramethyl orthosilicate (TMOS) is popularly used in the sol-gel synthesis of silicates1 and chromium-doped silicates and in the formation of hexagonal mesoporous silica layers.
Used in the sol-gel synthesis of chromium-doped silicates and in the formation of hexagonal mesoporous silica layers.

Signal Word

Danger

Hazard Statements

H226,H315,H318,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

78.8 °F - closed cup

Flash Point(C)

26 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yonghao Xiu et al.
Journal of colloid and interface science, 326(2), 465-470 (2008-07-29)
A method for the preparation of inorganic superhydrophobic silica coatings using sol-gel processing with tetramethoxysilane and isobutyltrimethoxysilane as precursors is described. Incorporation of isobutyltrimethoxysilane into silica layers resulted in the existence of hydrophobic isobutyl surface groups, thereby generating surface hydrophobicity.
Yun Tian et al.
Electrophoresis, 29(4), 960-970 (2008-01-24)
A novel calix[4] open-chain crown ether (p-tert-butylcalix[4]arene-1,3-bis(allyloxyethy) ether)-modified, organic-inorganic hybrid silica-based monolithic column possessing vinyl ligands for CEC is described. The monolithic silica matrix containing a vinyl functionality was synthesized by in situ cocondensation of tetramethoxysilane (TMOS) and vinyltrimethoxysilane (VTMS)
Akhilesh Rai et al.
Langmuir : the ACS journal of surfaces and colloids, 26(6), 4152-4159 (2009-12-17)
We report an elegant and simple method to fabricate uniform silica films with controlled thickness, roughness, and hydrophilicity using nanogram quantities of silicatein, a protein involved in silica synthesis in sponges. The formation of uniform silica films was achieved by
Microemulsion-mediated self-assembly and silicification of mesostructured ferritin nanocrystals.
Elizabeth M Lambert et al.
Angewandte Chemie (International ed. in English), 49(24), 4100-4103 (2010-04-29)
Zian Lin et al.
Chemical communications (Cambridge, England), 47(34), 9675-9677 (2011-07-30)
An inorganic-organic hybrid affinity monolithic column was synthesized by a novel "one-pot" approach. The resulting hybrid affinity monoliths have potential applications in specific recognition and enrichment of glycoproteins.
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