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Sigma-Aldrich

1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide

suitable for fluorescence, ≥97.0% (TLC)

Synonym(s):

(6-Methoxyquinolinio)acetic acid ethyl ester bromide, MQAE

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About This Item

Empirical Formula (Hill Notation):
C14H16BrNO3
CAS Number:
162558-52-3
Molecular Weight:
326.19
MDL number:
MFCD00467854
UNSPSC Code:
12352106
PubChem Substance ID:
329757076
NACRES:
NA.32

Assay

≥97.0% (TLC)

form

solid

mp

177-179 °C (lit.)

solubility

DMSO: soluble
H2O: soluble
methanol: soluble

fluorescence

λex 350 nm; λem 460 nm in 0.1 M borate pH 8.0 (quenching with Cl-)

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

[Br-].CCOC(=O)C[n+]1cccc2cc(OC)ccc12

InChI

1S/C14H16NO3.BrH/c1-3-18-14(16)10-15-8-4-5-11-9-12(17-2)6-7-13(11)15;/h4-9H,3,10H2,1-2H3;1H/q+1;/p-1

InChI key

DSLLHVISNOIYHR-UHFFFAOYSA-M

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Application

1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide, a fluorescent chloride indicator dye, may be used to measure intracellular and extracellular chloride concentrations.

Other Notes

Improved chloride probe. Used to measure chloride transport in liposome membranes

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Journal of neurophysiology, 100(1), 169-184 (2008-04-04)
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Analytical biochemistry, 178(2), 355-361 (1989-05-01)
A class of N-substituted quinoline compounds has been introduced recently for the fluorescence measurement of Cl concentration in biological preparations. The most Cl-sensitive compound was 6-methoxy-N-[3-sulfopropyl] quinolinium with peak excitation and emission wavelengths of 350 and 442 nm and a
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