Z0127

Zatebradine hydrochloride

≥98% (HPLC), powder

• Sinónimos: 7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride, UL-FS49
• Fórmula empírica (notación de Hill): C₂₆H₃₇ClN₂O₅
• Número de CAS: 91940-87-3
• Peso molecular: 493.04
• Número MDL: MFCD06798356
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24724672
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white
• solubilidad: H₂O: >10 mg/mL
• emisor: Boehringer Ingelheim
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
• InChI: 1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H
• Clave InChI: ZRNKXJHEQKMWCH-UHFFFAOYSA-N

Descripción

Aplicación

Zatebradine hydrochloride has been used:

• as an I_f blocker to study its effects on cardiomyocyte clusters (CMCs) [1]
• as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice [2]
• as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish [3]

Acciones bioquímicas o fisiológicas

HCN channel blocker: blocker of neuronal I_h, related cardiac I_f channels and ATP-sensitive K_ir channels.

Zatebradine is a bradycardiac agent.[4]

Características y beneficios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)