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SRP4903

Sigma-Aldrich

Adiponectin from rat

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sinónimos:

ACDC, APM-1, Acrp30, AdipoQ, GBP-28

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

rat

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

lyophilized

mol wt

~30 kDa

packaging

pkg of 25 μg

impurities

endotoxin, tested

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

General description

Adiponectin (also called Acrp30, AdipoQ) is an adipocyte specific secreted protein[1] that circulates in the plasma. It is induced during adipocyte differentiation[1] and the secretion is stimulated by insulin.

Biochem/physiol Actions

Adiponectin plays a role in various physiological processes such as energy homeostasis and obesity. Plasma levels of adiponectin are reduced in obese humans, and decreased levels are associated with insulin resistance and hyperinsulinemia. Adiponectin regulates vascular function, sustains an anti-inflammatory environment and promotes angiogenesis.[1][2]

Physical form

Lyophilized from a 0.2 μm filtered solution in 25 mM Tris, 0.15 M NaCl, pH 7.4 containing 50 μg of bovine serum albumin (BSA) per 1 μg of adiponectin.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Recontitute in PBS containing at least 0.1% BSA to a concentration of 0.1-1.0 mg/mL. This stock solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Deficiency of adiponectin protects against ovariectomy-induced osteoporosis in mice.
Wang F
PLoS ONE, 8(7), e68497-e68497 (2013)
Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesity.
Aprahamian TR
Metabolism and Disease, 62(12), 1730-1738 (2013)
Sergio García-Méndez et al.
Medicine, 94(26), e935-e935 (2015-07-02)
The aim of this study was to determine the levels of leptin (Lep) and adiponectin (AdipoQ) in patients with gout and its relationship with joint inflammatory data and/or with metabolic syndrome (MetS) variables, during 1 year follow-up.Forty-one patients (40 males)
Marcia J Abbott et al.
PloS one, 10(7), e0134290-e0134290 (2015-08-01)
Epidemiological studies show that high circulating levels of adiponectin are associated with low bone mineral density. The effect of adiponectin on skeletal homeostasis, on osteoblasts in particular, remains controversial. We investigated this issue using mice with adipocyte-specific over-expression of adiponectin

Artículos

Lipid Induced Insulin Resistance

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