SRP2124
Dr1 (NC2β, 19 kDa), GST tagged human
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sinónimos:
NC2, NC2-beta
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10 μG
MXP 8,390.00
MXP 8,390.00
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10 μG
MXP 8,390.00
About This Item
Código UNSPSC:
12352202
NACRES:
NA.26
MXP 8,390.00
Check Cart for Availability
origen biológico
human
recombinante
expressed in E. coli
Ensayo
≥80% (SDS-PAGE)
Formulario
frozen liquid
mol peso
~46.2 kDa
envase
pkg of 10 μg
concentración
500 μg/mL
color
colorless to clear
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... DR1(1810)
Acciones bioquímicas o fisiológicas
Dr1 is a general negative regulator of class II and class III gene expression. It binds to the basic repeat domain of TBP on promoter DNA and can prevent the RNA polymerase II holoenzyme, or its TFIIB and/or TFIIA subunits, from assembling into an initiation complex. Dr1 is phosphorylated in vivo and this modification affects its interaction with TBP. In addition, Dr1 interacts with the hyperphosphorylated form of Pol II and with the repression domain of the AREB6 repressor. Dr1 forms a heterodimer complex with DRAP1 through its histone fold domain. More recently it was discovered that Dr1-DRAP1 is a bi-functional basal transcription factor that differentially regulates gene transcription through DPE (downstream promoter elements) or TATA box motifs. It can stimulate transcription in vitro from Drosophila promoters containing DPEs, whereas it represses transcription from TATA-containing promoters.
Forma física
Clear and colorless frozen liquid solution
Nota de preparación
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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R J White et al.
Science (New York, N.Y.), 266(5184), 448-450 (1994-10-21)
RNA polymerases I, II, and III each use the TATA-binding protein (TBP). Regulators that target this shared factor may therefore provide a means to coordinate the activities of the three nuclear RNA polymerases. The repressor Dr1 binds to TBP and
J A Inostroza et al.
Cell, 70(3), 477-489 (1992-08-07)
We have discovered a protein termed Dr1 that interacts with the TATA-binding protein, TBP. The association of Dr1 with TBP results in repression of both basal and activated levels of transcription. The interaction of Dr1 with TBP precludes the formation
F Mermelstein et al.
Genes & development, 10(8), 1033-1048 (1996-04-15)
A Dr1-associated polypeptide (DRAP1) was isolated from HeLa cells and found to function as a corepressor of transcription. Corepressor function requires an interaction between DRAP1 and Dr1. Heterodimer formation was dependent on a histone fold motif present at the amino
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