DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
Synonyms:
NC2, NC2-BETA
Species:
Human DR1 (1810), Mouse Dr1 (13486), Rat Dr1 (289881), Zebrafish dr1 (768171), chicken DR1 (424496), cow DR1 (613828), domestic cat DR1 (101098807), dog DR1 (479943), sheep DR1 (101105865), naked mole-rat Dr1 (101707064)
UniProtKB ID:
Gene ID:
- Human(1810) Summary: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]
- Mouse(13486) down-regulator of transcription 1
- Rat(289881) down-regulator of transcription 1
- Zebrafish(768171) down-regulator of transcription 1
- chicken(424496) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
- cow(613828) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
- domestic cat(101098807) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
- dog(479943) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
- sheep(101105865) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
- naked mole-rat(101707064) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
- domestic guinea pig(100724062) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-DR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-DR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-DR1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
western blot
Proteins
Product Number
Description
Species
Dr1 (NC2β, 19 kDa), GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human