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SRP2081

Sigma-Aldrich

Retinoblastoma protein human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Sinónimos:

OSRC, RB, p105-Rb, pRb, pp110, retinoblastoma 1

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5 μG
MXP 14,497.00

MXP 14,497.00

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5 μG
MXP 14,497.00

About This Item

Código UNSPSC:
12352202
NACRES:
NA.26

MXP 14,497.00

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origen biológico

human

recombinante

expressed in insect cells

Ensayo

≥70% (SDS-PAGE)

Formulario

frozen liquid

mol peso

~107.5 kDa

envase

pkg of 5 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

concentración

400 μg/mL

color

clear colorless

Nº de acceso NCBI

NM_000321

Nº de acceso UniProt

P06400

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... RB1(5925)

Descripción general

The gene encoding retinoblastoma-associated protein (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2.[1]

Acciones bioquímicas o fisiológicas

pRB, the product of retinoblastoma susceptibility gene RB-1, is one of the best-studied tumor suppressor gene products. At least two other pRB-related proteins, p107 and p130, have been identified and characterized. Mutations in RB-1 gene are often associated with the occurrence of various tumors. The activity of pRB is regulated through phosphorylation in a cell cycle-dependent manner. The hyperphosphorylated RB protein usually associates with the cell nucleus and binds transcription factors of the E2F family. pRB represses transcription of its target genes, such as cdc2, cyclin A, and oncogene c-Myc, c-Fos through the binding with E2F factors and thereby regulating cell proliferation.

Forma física

Clear and colorless frozen liquid solution

Nota de preparación

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
072180136
67206128
051011022

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Thao T Le et al.
Chemical science, 11(17), 4467-4474 (2020-04-21)
Although RNA aptamers can show comparable or better specificity and affinity to antibodies and have the advantage of being able to access different live cell compartments, they are often much less stable in vivo. We report here the first aptamer
S H Friend et al.
Nature, 323(6089), 643-646 (1986-10-16)
The genomes of various tumour cells contain mutant oncogenes that act dominantly, in that their effects can be observed when they are introduced into non-malignant cells. There is evidence for another class of oncogenes, in which tumour-predisposing mutations are recessive
Z Onadim et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(13), 6177-6181 (1992-07-01)
The retinoblastoma-predisposition gene, RB1, segregates as an autosomal dominant trait with high (90%) penetrance. Certain families, however, show an unusual low-penetrance phenotype with many individuals being unaffected, unilaterally affected, or with evidence of spontaneously regressed tumors. We have used single-strand
W H Lee et al.
Science (New York, N.Y.), 235(4794), 1394-1399 (1987-03-13)
Recent evidence indicates the existence of a genetic locus in chromosome region 13q14 that confers susceptibility to retinoblastoma, a cancer of the eye in children. A gene encoding a messenger RNA (mRNA) of 4.6 kilobases (kb), located in the proximity
Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL).
Lens D
Leukemia, 14(3), 427-430 (2000)

Questions

1–3 of 3 Questions  

  1. Is there a tag still present or is it cleaved off at the time of purification for Product SRP2081, Retinoblastoma protein human?

    1 answer

    1. Product SRP2081, Retinoblastoma protein human, has a 6X His-tag attached to its N-terminus.

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  2. What is the composition of the buffer which Product SRP2081, Retinoblastoma protein human, is offered in?

    1 answer

    1. Product SRP2081, Retinoblastoma protein human, is provided in a buffer consisting of: 20 mM Tris-HCl (pH 8.0), 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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