SML1779

Nigericin sodium salt

from Streptomyces hygroscopicus, ≥98% (HPLC), solution, polyether ionophore

• Sinónimos: 3B2-6379, Antibiotic K178, Antibiotic X464, Azalomycin M, HE331800, Helexin C, Polyetherin A, sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate
• Fórmula empírica (notación de Hill): C₄₀H₆₇NaO₁₁
• Número de CAS: 28643-80-3
• Peso molecular: 746.94
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Nigericin sodium salt Ready Made Solution, 5 mg/mL (DMSO:ethanol 1:1)
• origen biológico: Streptomyces hygroscopicus
• Nivel de calidad: 200
• Formulario: solution
• concentración: 5 mg/mL (DMSO:ethanol 1:1)
• espectro de actividad antibiótica: Gram-positive bacteria
• Modo de acción: cell membrane | interferes
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [Na+].[O-]C(=O)C(C1O[C@H](CC[C@@H]1C)C[C@H]2O[C@]3(OC(CC3C)(C4OC(CC4)(C5O[C@H](C[C@@H]5C)[C@H]6O[C@@]([C@@H](C[C@@H]6C)C)(O)CO)C)C)[C@@H]([C@@H](C2)OC)C)C
• InChI: 1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
• Clave InChI: MOYOTUKECQMGHE-KKCUGXASSA-M

Descripción

Acciones bioquímicas o fisiológicas

Nigericin is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K⁺) for H⁺ (antiport).

Nigericin is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K⁺) for H⁺ (antiport). Nigericin transports monovalent cations across membranes with the following specificity: K⁺ >Rb⁺ >Cs⁺ >>Na⁺ and thus, disrupts membrane potential and stimulates ATPase activity in mitochondria.
Nigericin kills bacteria by facilitating the diffusion of ions across membranes.
Low concentration (0.5 μM) of Nigericin rapidly decreases pHi, causing stimulation of PG production 1.5- to 2-fold in cerebral microvascular endothelial cells and arresting of DNA synthesis in Erlich acites carcinoma cells. Treatment of Hela cells, after entry of poliovirus, with nigericin, prevents the inhibition of host protein synthesis by poliovirus. Nigericin is also widely used in studies of the consequences of changes in membrane potential in variable systems.

Nota de preparación

Nigericin sodium salt ready made solution is provided at 6.7 mM concentration. The solution can be further diluted with a desired solvent to a working concentration (0.5-10 μM).

This product is a 5 mg/mL solution prepared in a 1:1 mixture of DMSO and Ethanol.

Almacenamiento y estabilidad

The product can be stored at 2-8°C and is released with a 4 years suggested retest schedule. The solution is quite stable refrigerated and freezing is not necessary.

Información de seguridad

• Pictogramas: GHS02
• Palabra de señalización: Warning
• Frases de peligro: H226
• Consejos de prudencia: P210 - P233 - P240 - P241 - P242 - P243
• Clasificaciones de peligro: Flam. Liq. 3
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 78.8 °F
• Punto de inflamabilidad (°C): 26 °C