SML1142

VU0071063

≥98% (HPLC)

• Sinónimos: 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
• Fórmula empírica (notación de Hill): C₁₈H₂₂N₄O₂
• Número de CAS: 333415-38-6
• Peso molecular: 326.39
• Número MDL: MFCD02648040
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825676
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CN(C1=C2N(CC3=CC=C(C(C)(C)C)C=C3)C=N1)C(N(C)C2=O)=O
• InChI: 1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3
• Clave InChI: ZFZAIHKQJBMYLO-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

VU0071063 is a potent activator of Kir6.2/SUR1 KATP channels (EC₅₀ = 10.3 μM). VU0071063 reversibly inhibits glucose-stimulated calcium influx in mouse β-islet cells. The compound VU0071063 has no affect on Kir6.2/SUR2A channels.

VU0071063 is a specific activator of SUR1-containing KATP channels.

VU0071063 is also known as [7-(4-(tert-butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione]. It serves as a major compound for examining β-cell physiology, K_ATP channel gating and a new chemical scaffold for evolving enhanced activators with medicinal chemistry.[1]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable