SML0847

Benztropine mesylate

≥98% (HPLC)

• Sinónimos: Benzatropine mesylate, Benzotropine mesylate, Benztropine methanesulfonate
• Fórmula empírica (notación de Hill): C₂₁H₂₅NO · CH₃SO₃H
• Número de CAS: 132-17-2
• Peso molecular: 403.53
• Número CE: 205-048-8
• Número MDL: MFCD00074784
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825609
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: H₂O: 20 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c3ccccc3)c4ccccc4
• InChI: 1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+;
• Clave InChI: CPFJLLXFNPCTDW-BWSPSPBFSA-N
• Información sobre el gen: human ... CHRM1(1128)

Descripción

Descripción general

Benztropine mesylate is an anti-histamine and dopamine re-uptake inhibitor.[1]

Aplicación

Benztropine mesylate has been used to study its target identification and mode of action against ebolavirus infection.[2] It has also been used in pharmacological animal studies to evaluate its effect on SLC6A19 (solute carrier family 6 member 19; B0AT1).[3]

Acciones bioquímicas o fisiológicas

Benztropine mesylate is a centrally acting muscarinic acetylcholine receptor antagonist and dopamine transporter (DAT) inhibitor (IC₅₀ = 118 nM). Benztropine mesylate has been used to treat the symptoms of Parkinson′s disease and is currently in clincial trials for chronic back pain.

Benztropine mesylate is a muscarinin acetylcholine receptor antagonist.

Benztropine mesylate serves as an inhibitor of breast cancer stem cells (BCSCs) in vitro and in vivo. It can help in improving the efficacy of chemotherapy in vitro. It is considered as an anti-cancer stem cell (CSC) drug, which can modify tumorigenic properties.[1]

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) and Biogenic Amine Transporters pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H302,H311 + H331
• Consejos de prudencia: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable