P9178

Prochlorperazine dimaleate salt

• Fórmula empírica (notación de Hill): C₂₀H₂₄ClN₃S · 2C₄H₄O₄
• Número de CAS: 84-02-6
• Peso molecular: 606.09
• EC Number: 201-511-3
• MDL number: MFCD00069330
• UNSPSC Code: 41116107
• PubChem Substance ID: 57654570
• NACRES: NA.77

Propiedades

• form: powder
• Quality Level: 200
• solubility: H₂O: slightly soluble 0.3 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3 mg/mL; methanol: soluble
• originator: GlaxoSmithKline
• SMILES string: OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1
• InChI: 1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
• InChI key: DSKIOWHQLUWFLG-SPIKMXEPSA-N
• Gene Information: human ... DRD2(1813)

Descripción

Biochem/physiol Actions

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist; antispasmodic

Prochlorperazine is an anti-nausea and neuroleptic agent. It is known to cause neuropsychiatric side effects.[1] Prochlorperazine inhibits the action of dopamine in the central nervous system. It acts as an antiemetic drug and prevents vomiting and stimulates sleep. Prochlorperazine is useful as a tranquilizer in the treatment of schizophrenia and nonpsychotic anxiety.[2]

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H336,H361d,H362
• pcodes: P202 - P260 - P263 - P264 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Lact. - Repr. 2 - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves