Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

Ver Toda la documentación

S7076

Sigma-Aldrich

SB 202190 monohydrochloride hydrate

≥98% (HPLC), solid, p38 MAP kinase inhibitor

Sinónimos:

4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate, 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización

Seleccione un Tamaño

5 MG
MXP 2,796.00
25 MG
MXP 11,373.00

MXP 2,796.00

Check Cart for Availability
Solicitar un pedido a granel
Todas las fotos(1)

Seleccione un Tamaño

Cambiar Vistas
5 MG
MXP 2,796.00
25 MG
MXP 11,373.00

About This Item

Fórmula empírica (notación de Hill):
C20H14FN3O · HCl · xH2O
Número de CAS:
350228-36-3
Peso molecular:
367.80 (anhydrous basis)
Número MDL:
MFCD17215958
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329824576
NACRES:
NA.77

MXP 2,796.00

Check Cart for Availability
Solicitar un pedido a granel

Nombre del producto

SB 202190 monohydrochloride hydrate, ≥98% (HPLC)

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

solid

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

DMSO: ≥12 mg/mL

emisor

GlaxoSmithKline

temp. de almacenamiento

2-8°C

cadena SMILES

O.Cl.Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H14FN3O.ClH.H2O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;;/h1-12,25H,(H,23,24);1H;1H2

Clave InChI

CZZOICWZVYZUNP-UHFFFAOYSA-N

Aplicación

SB 202190 may be used to inhibit p38-mediated cell signaling.
SB 202190 monohydrochloride hydrate has been used as a component of human prostate culture medium[1] and organoid culture medium[2] It has also been used as p38 mitogen activated protein kinase (MAPK) inhibitor in colon cancer cells.[3]

Acciones bioquímicas o fisiológicas

SB 202190 binds within the ATP pocket of p38 kinase and inhibits the p38α and β isoforms.
SB 202190 is a highly selective, potent, and cell-permeable inhibitor of p38 MAP kinase.
SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines.[4]

Características y beneficios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
0000429926
0000429926
0000377526
0000377526
0000258148

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Organoid culture systems for prostate epithelial and cancer tissue
Drost J, et al.
Nature Protocols, 11(2), 347-347 (2016)
Differential effects of p38 MAP kinase inhibitors SB203580 and SB202190 on growth and migration of human MDA-MB-231 cancer cell line
Duzgun SA, et al.
Cytotechnology, 69(4), 711-724 (2017)
Organoid culture of human prostate cancer cell lines LNCaP and C4-2B
Ma L, et al.
American journal of clinical and experimental urology, 5(3), 25-25 (2017)
Hanbing Song et al.
Nature communications, 13(1), 141-141 (2022-01-12)
Prostate cancer is the second most common malignancy in men worldwide and consists of a mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived
Michalis Mastri et al.
American journal of clinical and experimental urology, 9(6), 416-434 (2022-01-08)
The evolving paradigm of the molecular classification of bladder cancer requires models that represent the classifications with less heterogeneity. Robust transcriptome based molecular classifications are essential to address tumor heterogeneity. Patient derived models (PDMs) are a powerful preclinical tool to
Ver todos los artículos relacionados

Artículos

Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

3D Organoid Culture: New In Vitro Models of Development and Disease

Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.

Questions

Reviews

No rating value

Active Filters

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico