P215

PD 98,059

solid

• Sinónimos: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
• Fórmula empírica (notación de Hill): C₁₆H₁₃NO₃
• Número de CAS: 167869-21-8
• Peso molecular: 267.28
• Número MDL: MFCD00671789
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278666
• NACRES: NA.77

Propiedades

• Formulario: solid
• color: yellow
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: −20°C
• cadena SMILES: COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
• InChI: 1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
• Clave InChI: QFWCYNPOPKQOKV-UHFFFAOYSA-N
• Información sobre el gen: human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)

Descripción

Aplicación

PD 98,059 has been used:

• in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors[1]
• in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown[2]
• in culture medium for cell migration assay[3]

Acciones bioquímicas o fisiológicas

PD 98,059 is a flavonoid[4] and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock.[5] It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.[6]

Características y beneficios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información legal

Sold with permission of Warner Lambert Company.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves