P0869
Monoclonal Anti-Peroxisome Proliferator Activated Receptor α antibody produced in mouse
~1 mg/mL, clone 3B6/PPAR, purified immunoglobulin, buffered aqueous solution
Sinónimos:
Anti-PPARα
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100 μG
MXP 11,355.00
MXP 11,355.00
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100 μG
MXP 11,355.00
About This Item
MXP 11,355.00
Check Cart for Availability
Productos recomendados
origen biológico
mouse
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
3B6/PPAR, monoclonal
Formulario
buffered aqueous solution
reactividad de especies
mouse, rat, human
concentración
~1 mg/mL
técnicas
western blot: 2-5 μg/mL using human, mouse and rat
isotipo
IgG2b
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... PPARA(5465)
mouse ... Ppara(19013)
rat ... Ppara(25747)
Descripción general
Peroxisome proliferator-activated receptors (PPARs) are a group of closely related nuclear receptors. Three PPAR isotypes have been identified: α,β (also called NUC1) and γ. PPARa mRNA is expressed most in brown adipose tissue, heart, liver and kidney in rats. The gene encoding PPARα is localized on human chromosome 22q12-q13.1 and rat chromosome 7q34.
Inmunógeno
purified recombinant PPARα protein.
Acciones bioquímicas o fisiológicas
Peroxisome proliferator-activated receptors (PPARs) may be involved in chronic diseases such as diabetes, obesity, atherosclerosis and cancer. PPARα has a protective function in fatty acids overload associated tubular injury. The enzyme also has a role in fatty acid oxidation and metabolism.
Forma física
Solution in phosphate buffered saline containing 1 mg/ml bovine serum albumin and 0.05% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Maria L R Hughes et al.
The Journal of biological chemistry, 290(22), 13895-13906 (2015-04-08)
Nuclear hormone receptors (NHRs) regulate the expression of proteins that control aspects of reproduction, development and metabolism, and are major therapeutic targets. However, NHRs are ubiquitous and participate in multiple physiological processes. Drugs that act at NHRs are therefore commonly
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
Be?atrice Desvergne and Walter Wahli
Endocrine Reviews, 20(5), 649?688-649?688 (1999)
Fenofibrate, a PPAR? agonist, protect proximal tubular cells from albumin-bound fatty acids induced apoptosis via the activation of NF-kB
Nan Zuo
International Journal of Clinical and Experimental Pathology, 8(9), 10653?10661-10653?10661 (2015)
C W Park et al.
Kidney international, 69(9), 1511-1517 (2006-05-05)
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the ligand-activated nuclear receptor superfamily, and plays an important role in lipid metabolism and glucose homeostasis. The purpose of this study is to determine whether the activation of PPARalpha by fenofbrate
PPARs: molecular targets in the pharmacogenomics era
Prague Medical Report, 223-236 (2004)
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