This product is analyzed for solubility in DMSO at ≥ 10.0 mg/ mL on a lot to lot basis. The MML references the solubility in mg/mL.
O9890
5Z-7-Oxozeaenol
≥98% (HPLC), powder, TAK1 inhibitor
Sinónimos:
C 292, F 152, FR148083, L 783279, LL-Z1640-2
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1 MG
MXP 4,611.00
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1 MG
MXP 4,611.00
About This Item
Fórmula empírica (notación de Hill):
C19H22O7
Número de CAS:
Peso molecular:
362.37
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
Nombre del producto
5Z-7-Oxozeaenol, ≥98% (HPLC)
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
powder
color
white to off-white
solubilidad
DMSO: >10 mg/mL
temp. de almacenamiento
2-8°C
cadena SMILES
COc1cc(O)c2C(=O)O[C@@H](C)CC=CC(=O)[C@@H](O)[C@@H](O)C\C=C\c2c1
InChI
1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
Clave InChI
NEQZWEXWOFPKOT-BYRRXHGESA-N
Aplicación
5Z-7-Oxozeaenol has been used:
- as transforming growth factor β-activated kinase 1 (TAK1) inhibitor to treat human colon cancer cells[1]
- as TAK1-specific inhibitor to provide intraperitoneal injection to mice for aortic banding[2]
- as TAK1 inhibitor to treat cells for luciferase reporter assay[3]
- to test growth and differentiation factor 2 (GDF2)-mediated anoikis[4]
Acciones bioquímicas o fisiológicas
5Z-7-oxozeaenol is a potent ATP-competitive irreversible inhibitor of ERK2 (IC50 = 80 nM), TAK1 (MEKK7), MKK7, and MEK1, which all contain a common cysteine residue in the ATP-binding site. 5Z-7-oxozeaenol has no activity against other MAP kinases. 5Z-7-oxozeaenol is also anti-inflammatory.
The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy.[2]
Características y beneficios
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the MAPKKKs and MAPKs pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Los clientes también vieron
Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor beta-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells
Hrabe JE, et al.
Redox Biology, 5, 319-327 (2015)
Gang Wang et al.
Journal of cellular and molecular medicine, 25(14), 6584-6601 (2021-06-03)
Gastric cancer (GC) is the most frequent digestive system malignant tumour and the second most common cause of cancer death globally. Cancer stem cell (CSC) is a small percentage of cancer cells in solid tumours that have differentiation, self-renewal and
Epigenetic regulation of GDF2 suppresses anoikis in ovarian and breast epithelia
Varadaraj A, et al.
Neoplasia, 17(11), 826-838 (2015)
Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway
Li CY, et al.
Basic Research in Cardiology, 111(2), 19-19 (2016)
Cytosolic Internalization of Anti-DNA Antibodies by Human Monocytes Induces Production of Pro-Inflammatory Cytokines Independently of the Tripartite Motif-Containing 21 (TRIM21)-Mediated Pathway
Park H, et al.
Frontiers in Immunology, 9 (2018)
Artículos
The extracellular signal regulated kinase (ERK1 and ERK2) pathways are activated by mitogens and play an important role in controlling cell growth and differentiation.
The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
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En el CoA de este producto (5Z-7-Oxozeaenol) la concentración en DMSO aparece expresada en MML. ¿Podrían aclararme qué significan esas unidades?¿Masa x vol?¿mmol/L?Porque no consigo encontrar ninguna referencia de concentraciones expresadas en MML.Gracias
1 answer-
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