N9037

Necrostatin-1

≥98% (HPLC), powder, necroptosis inhibitor

• Sinónimos: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone, 5-(Indol-3-ylmethyl)-3-methyl-2-thio-Hydantoin, MTH-DL-Tryptophan
• Fórmula empírica (notación de Hill): C₁₃H₁₃N₃OS
• Número de CAS: 4311-88-0
• Peso molecular: 259.33
• Número MDL: MFCD00056916
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24724559
• NACRES: NA.77

Propiedades

• Nombre del producto: Necrostatin-1, ≥98% (HPLC)
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: CN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O
• InChI: 1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
• Clave InChI: TXUWMXQFNYDOEZ-UHFFFAOYSA-N

Descripción

Aplicación

Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro.[1] It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies.[2][3]

Acciones bioquímicas o fisiológicas

Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway).

Necrostatin-1(Nec-1) might exhibit therapeutic benefit against patients with traumatic brain injury (TBI). In addition, it might also be used to treat other acute central nervous system (CNS) disorders that feature necroptosis as a mode of cell death.[4] It is extensively used to study the effect of receptor-interacting protein kinase 1 (RIPK1) on cell death and inflammation in experimental disease models.[5] Nec‐1 protects hippocampal (HT‐22) cells from glutamate‐induced oxytosis via increasing cellular glutathione (GSH) levels, decreasing reactive oxygen species production, inhibiting the nuclear translocation of apoptosis‐inducing factor and B-cell lymphoma 2 (Bcl‐2) /adenovirus E1B 19kDa‐interacting protein 3‐related pathways.[6]

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)