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MAK090

Sigma-Aldrich

γ-Glutamyltransferase (GGT) Activity Fluorometric Assay Kit

sufficient for 100 fluorometric tests

Sinónimos:

Gamma Glutamyltransferase Activity Fluorometric Assay Kit

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About This Item

Número CE:
200-664-3
Código UNSPSC:
12352200

uso

sufficient for 100 fluorometric tests

método de detección

fluorometric

temp. de almacenamiento

−20°C

Información sobre el gen

human ... GGT1(2678) , GGT2(728441) , GGT5(2687) , GGT6(124975) , GGT7(2686)
mouse ... GGT1(14598) , GGT5(23887) , GGT6(71522) , GGT7(207182)
rat ... GGT1(116568) , GGT5(296566) , GGT6(408206) , GGT7(156275)

Descripción general

γ-Glutamyltransferase (GGT, EC 2.3.2.2) is a membrane-bound protein that catalyzes the transfer of γ-glutamyl moieties to acceptor molecules such as amino acids or peptides. GGT plays a key role in the γ-glutamyl cycle, a critical pathway for glutathione homeostasis as well as the detoxification of xenobiotics. Serum GGT levels can be elevated in many pathophysiological conditions such as cardiovascular disease, chronic liver disease, and metabolic syndrome. Elevated serum levels of GGT can also be indicative of oxidative stress.[1]

Aplicación

γ-Glutamyltransferase (GGT) Activity Fluorometric Assay Kit has been used to analyze serum GGT activity.[2][3]

Características y beneficios

Compatible with high-throughput handling systems.

Idoneidad

Suitable for the measurement of gamma-glutamyl transferase (GGT) in a variety of samples including tissue, cells and serum

Principio

The GGT Activity Fluorometric Assay kit provides a simple and direct procedure for measuring GGT activity in a variety of samples. GGT activity is determined by a coupled enzyme assay, in which the GGT transfers the γ-glutamyl group from quenched substrate L-γ-Glutamyl-7-amido-4-methylcoumarin (L--Glutamyl-AMC), liberating the fluorescent group, 7-Amino-4-Methyl Coumarin (AMC) (λex = 365 nm/λem = 460 nm) proportional to the GGT activity present. One unit of GGT is the amount of enzyme that will generate 1.0 μmole of AMC per minute at 37 °C.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

188.6 °F - closed cup

Punto de inflamabilidad (°C)

87 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number
8F09K07850
6C05K07850
5J25K07850
4G11K07850
4C06K07850

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Ruben Weckx et al.
Scientific reports, 12(1), 10591-10591 (2022-06-23)
In septic mice, 3-hydroxybutyrate-sodium-salt has shown to partially prevent sepsis-induced muscle weakness. Although effective, the excessive sodium load was toxic. We here investigated whether ketone ester 3-hydroxybutyl-3-hydroxybutanoate (3HHB) was a safer alternative. In a mouse model of abdominal sepsis, the
An ultrasensitive bioluminogenic probe of ?-Glutamyltranspeptidase in vivo and in human serum for tumor diagnosis.
Li S, et al.
Biosensors And Bioelectronics, 98, 325-329 (2017)
A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice.
Passman A M, et al.
Disease models & mechanisms, 8(12), 1635-1641 (2015)
Jia-Ru Wei et al.
Aging, 12(13), 13220-13233 (2020-07-09)
Gamma-glutamyltransferase 5 (GGT5) is a member of the gamma-glutamyl transpeptidase gene family with the capacity of cleaving the gamma-glutamyl moiety of glutathione, but its role in cancer progression has never been revealed. In this study, we found that gene GGT5
Gamma-glutamyl transferases: A structural, mechanistic and physiological perspective.
Balakrishna S and Asmita A P
Frontiers in Biology, 9(1), 51-65 (2014)
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