M8316
Anti-MRP2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-ABCC2, Anti-Multidrug Resistance Associated Protein 2, Anti-cMOAT, Anti-cMRP
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200 μL
MXP 11,648.00
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200 μL
MXP 11,648.00
About This Item
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen ~190 kDa
reactividad de especies
rat, human
técnicas
indirect immunofluorescence: 1:100 using paraformaldehyde-fixed HepG2 cells
indirect immunofluorescence: 1:100 using rat liver frozen sections
western blot: 1:1,000 using whole extract of HepG2 human hepatoblastoma cells
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... ABCC2(1244)
rat ... Abcc2(25303)
Categorías relacionadas
Descripción general
Multidrug Resistance-associated Protein 2 (MRP2), also called as canalicular Multispecific Organic Anion Transporter (cMOAT), is a member of the CFTR/MRP (ABCC) subfamily of the large ATP-Binding Cassette (ABC) transporter family of transmembrane proteins. MRP2 is normally expressed in the liver, gallbladder, kidney proximal tubules, placenta, duodenum and small intestine. Localization pattern appears to vary in different species. MRP2 is predominantly localized to the apical membrane of polarized cells.
Multidrug resistance associated protein 2 (MRP2) is expressed in endothelial cells of the blood-brain barrier, various carcinoma cell lines and tumors. The gene encoding MRP2 is localized on human chromosome 10q24 and consists of 32 exons.[1]
Especificidad
Additional lower bands including an approx. 175 kDa band representing an immature unglycosylated form may be detected in various extract preparations.
Inmunógeno
synthetic C-terminal peptide corresponding to amino acids 1528-1545 of human MRP2 conjugated to KLH.
Aplicación
Anti-MRP2 antibody produced in rabbit has been used in:
- immunoblotting
- western blotting
- immunofluorescence
Acciones bioquímicas o fisiológicas
Multidrug Resistance-associated Protein 2 (MRP2) transports endogenous and exogenous anionic conjugates from hepatocytes to the bile. Thus, it contributes to bile flow and plays a role in detoxification and defense against oxidative stress. Patients with the rare autosomal recessive Dubin-Johnson Syndrome develop a mild liver disease caused by MRP2 deficiency. Up regulation of MRP2 expression may be found in hepatocellular carcinomas.
Multidrug resistance associated protein 2 (MRP2) is a transporter which is involved in the efflux of various xenobiotic compounds like doxorubicin and methotrexate.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Barbara Schaarschmidt et al.
Theranostics, 8(14), 3766-3780 (2018-08-08)
Rationale: The liver is a central organ not only for metabolism but also immune function. Life-threatening infections of both bacterial and fungal origin can affect liver function but it is yet unknown whether molecular changes differ depending on the pathogen.
Biliary elimination of pemetrexed is dependent on Mrp2 in rats: Potential mechanism of variable response in nonalcoholic steatohepatitis
Dzierlenga Al, et al.
Journal of Pharmacology and Experimental Therapeutics, 358(2), 246-253 (2016)
Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance
Annereau JP, et al.
Molecular Pharmacology, 66(6), 1397-1405 (2004)
Peter Recknagel et al.
PLoS medicine, 9(11), e1001338-e1001338 (2012-11-16)
Hepatic dysfunction and jaundice are traditionally viewed as late features of sepsis and portend poor outcomes. We hypothesized that changes in liver function occur early in the onset of sepsis, yet pass undetected by standard laboratory tests. In a long-term
Yabin Duan et al.
Drug metabolism and disposition: the biological fate of chemicals, 50(2), 174-186 (2021-12-01)
Hypoxia is the main characteristic of a high-altitude environment, affecting drug metabolism. However, so far, the mechanism of microRNA (miRNA) involved in the regulation of drug metabolism and transporters under high-altitude hypoxia is still unclear. This study aims to investigate
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